Multiple assessments of non‐inferiority trials with ordinal endpoints
Sign Up to like & getrecommendations! Published in 2023 at "Statistics in Medicine"
DOI: 10.1002/sim.9660
Abstract: Non‐inferiority (NI) trials are implemented when there is a practical demand to search for alternatives to standard therapies, such as to reduce side effects. An experimental treatment is considered non‐inferior to the standard treatment when… read more here.
Keywords: inferiority; latent variable; non inferiority; inferiority trials ... See more keywords
Practical approaches to Bayesian sample size determination in non‐inferiority trials with binary outcomes
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DOI: 10.1002/sim.9661
Abstract: Bayesian analysis of a non‐inferiority trial is advantageous in allowing direct probability statements to be made about the relative treatment difference rather than relying on an arbitrary and often poorly justified non‐inferiority margin. When the… read more here.
Keywords: size; non inferiority; approach; sample size ... See more keywords
Dual-layer spectral detector CT: non-inferiority assessment compared to dual-source dual-energy CT in discriminating uric acid from non-uric acid renal stones ex vivo
Sign Up to like & getrecommendations! Published in 2018 at "Abdominal Radiology"
DOI: 10.1007/s00261-018-1589-x
Abstract: PurposeTo assess the non-inferiority of dual-layer spectral detector CT (SDCT) compared to dual-source dual-energy CT (dsDECT) in discriminating uric acid (UA) from non-UA stones.MethodsFifty-seven extracted urinary calculi were placed in a cylindrical phantom in a… read more here.
Keywords: dual layer; uric acid; dual energy; non inferiority ... See more keywords
Can We Perform CT of the Appendix with Less Than 1 mSv? A De-escalating Dose-simulation Study
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DOI: 10.1007/s00330-017-5159-3
Abstract: ObjectivesTo systematically explore the lowest reasonably achievable radiation dose for appendiceal CT using an iterative reconstruction (IR) in young adults.MethodsWe prospectively included 30 patients who underwent 2.0-mSv CT for suspected appendicitis. From the helical projection… read more here.
Keywords: non inferiority; non abdominal; abdominal radiologists; msv ... See more keywords
Non-inferiority multicenter prospective randomized controlled study of rectal cancer T2–T3s (superficial) N0, M0 undergoing neoadjuvant treatment and local excision (TEM) vs total mesorectal excision (TME)
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Colorectal Disease"
DOI: 10.1007/s00384-017-2942-1
Abstract: PurposeThe standard treatment of rectal adenocarcinoma is total mesorectal excision (TME), in many cases requires a temporary or permanent stoma. TME is associated with high morbidity and genitourinary alterations. Transanal endoscopic microsurgery (TEM) allows access… read more here.
Keywords: non inferiority; treatment; study; excision ... See more keywords
Non-Doppler hemorrhoidal artery ligation and hemorrhoidopexy combined with pudendal nerve block for the treatment of hemorrhoidal disease: a non-inferiority randomized controlled trial
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Colorectal Disease"
DOI: 10.1007/s00384-020-03768-8
Abstract: Background In this study, we proposed a combined outpatient treatment modality for hemorrhoidal disease. Methods This study was a prospective non-inferiority randomized controlled trial (RCT). The experimental group included the dearterialization and hemorrhoidopexy under pudendal… read more here.
Keywords: hemorrhoidal; trial; non inferiority; treatment ... See more keywords
Can whole-body MRI replace CT in management of metastatic testicular cancer? A prospective, non-inferiority study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-022-03996-1
Abstract: Concerns of imaging-related radiation exposure in young patients with high survival rates have increased the use of magnetic resonance imaging (MRI) in testicular cancer (TC) stage I. However, computed tomography (CT) is still preferred for… read more here.
Keywords: whole body; non inferiority; sensitivity; body ... See more keywords
Antimicrobial prophylaxis for 1 day versus 3 days in liver cancer surgery: a randomized controlled non-inferiority trial
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DOI: 10.1007/s00595-019-01813-w
Abstract: PurposesThis study compared the effectiveness of 1-day vs 3-days antibiotic regimen to prevent surgical site infection (SSI) in open liver resection.MethodWe performed a randomized controlled non-inferiority trial in 480 patients at 39 hospitals across Japan… read more here.
Keywords: day; day regimen; non inferiority; antimicrobial prophylaxis ... See more keywords
Non-efficacy benefits and non-inferiority margins: a scoping review of contemporary high-impact non-inferiority trials in clinical cardiology
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Epidemiology"
DOI: 10.1007/s10654-021-00820-x
Abstract: Randomized non-inferiority trials are designed to study whether an experimental treatment (or diagnostic test) is not unacceptably worse in terms of efficacy compared to the standard of care, whilst providing specific advantages over the standard… read more here.
Keywords: non inferiority; cardiology; non efficacy; inferiority ... See more keywords
Non-Inferiority Trials in Medicine: Practice Changing or a Self-Fulfilling Prophecy?
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DOI: 10.1007/s11606-017-4191-y
Abstract: E ach week, a practicing physician may read the latest medical journal and find a new intervention claiming to be non-inferior to a therapy she uses, while offering the advantage of freedom from monitoring, lower… read more here.
Keywords: medicine; non inferiority; medicine practice; trials medicine ... See more keywords
Methodological aspects of superiority, equivalence, and non-inferiority trials
Sign Up to like & getrecommendations! Published in 2020 at "Internal and Emergency Medicine"
DOI: 10.1007/s11739-020-02450-9
Abstract: Depending on the scientific hypothesis to be addressed, randomized-controlled trials (RCT) are accordingly designed. RCTs that aim to determine whether a novel, experimental therapeutic intervention (either a drug or a treatment) is superior to a… read more here.
Keywords: intervention; superiority; equivalence non; non inferiority ... See more keywords