A distinct epigenetic profile distinguishes stenotic from non-inflamed fibroblasts in the ileal mucosa of Crohn’s disease patients
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DOI: 10.1371/journal.pone.0209656
Abstract: Background The chronic remitting and relapsing intestinal inflammation characteristic of Crohn’s disease frequently leads to fibrosis and subsequent stenosis of the inflamed region. Approximately a third of all Crohn’s disease patients require resection at some… read more here.
Keywords: non inflamed; disease patients; disease; crohn disease ... See more keywords
Patients With Microscopic Colitis Have Altered Levels of Inhibitory and Stimulatory Biomarkers in Colon Biopsies and Sera Compared to Non-inflamed Controls
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DOI: 10.3389/fmed.2021.727412
Abstract: Introduction: Microscopic colitis (MC) is an inflammatory bowel condition with two subtypes, lymphocytic colitis (LC) and collagenous colitis (CC). Unlike patients with ulcerative colitis (UC) and non-inflamed individuals, MC patients have reduced risk of developing… read more here.
Keywords: non inflamed; compared controls; patients active; biopsies patients ... See more keywords
Non-Inflamed Tumor Microenvironment and Methylation/Downregulation of Antigen-Presenting Machineries in Cholangiocarcinoma
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DOI: 10.3390/cancers15082379
Abstract: Simple Summary Cholangiocarcinoma (CCA) is a chemotherapy-resistant cancer. Reportedly, combination chemotherapy that includes immune checkpoint inhibitors (ICIs) showed superior effects compared to conventional chemotherapy for the treatment of advanced CCA. Although the efficacy of ICIs… read more here.
Keywords: methylation; inflamed tumor; downregulation; non inflamed ... See more keywords
Inverse and Concordant Mucosal Pathway Gene Expressions in Inflamed and Non-Inflamed Ulcerative Colitis Patients: Potential Relevance to Aetiology and Pathogenesis
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DOI: 10.3390/ijms23136944
Abstract: Ulcerative colitis (UC) arises from a complex interplay between host and environmental factors, but with a largely unsolved pathophysiology. The pathophysiology was outlined by RNA-sequencing of mucosal biopsies from non-inflamed and inflamed colon of UC… read more here.
Keywords: inflamed mucosa; inflamed non; ulcerative colitis; gene ... See more keywords