Differences in Vector Genome Processing and Illegitimate Integration of Non-Integrating Lentiviral Vectors
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DOI: 10.1038/gt.2016.69
Abstract: A variety of mutations in lentiviral vector expression systems have been shown to generate a non-integrating phenotype. We studied a novel 12 base-pair U3-long terminal repeats (LTR) integrase (IN) attachment site deletion (U3-LTR att site)… read more here.
Keywords: integration; att site; ltr att; site ... See more keywords
Non-Integrating Lentiviral Vectors in Clinical Applications: A Glance Through
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DOI: 10.3390/biomedicines10010107
Abstract: Lentiviral vectors (LVs) play an important role in gene therapy and have proven successful in clinical trials. LVs are capable of integrating specific genetic materials into the target cells and allow for long-term expression of… read more here.
Keywords: clinical studies; expression; lentiviral vectors; integrating lentiviral ... See more keywords