Structure-Based Screening of Non-β-Lactam Inhibitors against Class D β-Lactamases: An Approach of Docking and Molecular Dynamics
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DOI: 10.1021/acsomega.0c00356
Abstract: The manifestation of class D β-lactamases in the community raises significant concern as they can hydrolyze carbapenem antibiotics. Hence, it is exceptionally alluring to design novel inhibitors. Structure-based virtual screening using docking programs and molecular… read more here.
Keywords: non lactam; structure based; class lactamases; molecular dynamics ... See more keywords
Search for non-lactam inhibitors of mtb β-lactamase led to its open shape in apo state: new concept for antibiotic design
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DOI: 10.1038/s41598-017-06023-3
Abstract: Mtb β-lactamase (BlaC) is extremely efficient in hydrolyzing ß-lactam antibiotics which renders/leads to protection and/or resistance to this bug. There is a compelling need to develop new non-lactam inhibitors which can bind and inhibit BlaC,… read more here.
Keywords: shape; blac; mtb lactamase; open shape ... See more keywords
In Vitro Susceptibility of Clinical Staphylococcus aureus Small-Colony Variants to β-Lactam and Non-β-Lactam Antibiotics
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DOI: 10.1128/aac.02532-17
Abstract: ABSTRACT The Staphylococcus aureus small-colony variant (SCV) phenotype has been associated with relapsing and antibiotic-refractory infections. However, little is known about the activities of antibiotics on clinical SCVs. Here, we demonstrated that SCVs without detectable… read more here.
Keywords: staphylococcus aureus; lactam non; aureus small; lactam antibiotics ... See more keywords
Prevalence, antibiotic profile, virulence determinants, ESBLs, and non-β-lactam encoding genes of MDR Proteus spp. isolated from infected dogs
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DOI: 10.3389/fgene.2022.952689
Abstract: This study investigated the prevalence, antibiogram, virulence, extended-spectrum β-lactamases (ESBLs), and non-β-lactam encoding genes of Proteus species isolated from infected dogs in Ismailia province, Egypt. The study was conducted on 70 fecal swabs collected from… read more here.
Keywords: prevalence; virulence; non lactam; encoding genes ... See more keywords
Molecular Basis of Non-β-Lactam Antibiotics Resistance in Staphylococcus aureus
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DOI: 10.3390/antibiotics11101378
Abstract: Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most successful human pathogens with the potential to cause significant morbidity and mortality. MRSA has acquired resistance to almost all β-lactam antibiotics, including the new-generation cephalosporins, and… read more here.
Keywords: staphylococcus aureus; resistance; non lactam; lactam antibiotics ... See more keywords