Structural basis for GPCR signaling by small polar versus large lipid metabolites-discovery of non-metabolite ligands.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in cell biology"
DOI: 10.1016/j.ceb.2019.12.005
Abstract: Key metabolites act through specific G protein-coupled receptors (GPCRs) as extracellular signals of fuel availability and metabolic stress. Here, we focus on the succinate receptor SUCNR1/GPR91 and the long chain fatty acid receptor FFAR1/GPR40, for… read more here.
Keywords: structural basis; basis gpcr; signaling small; small polar ... See more keywords
Structure-Activity Investigations and Optimisations of Non-metabolite Agonists for the Succinate Receptor 1
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-28263-7
Abstract: The succinate receptor 1 (SUCNR1) is a receptor for the metabolite succinate, which functions as a metabolic stress signal in the liver, kidney, adipose tissue and the retina. However, potent non-metabolite tool compounds are needed… read more here.
Keywords: receptor; succinate receptor; non metabolite; structure activity ... See more keywords