Heterocyclic and Alkyne Terpenoids by Terpene Synthase‐Mediated Biotransformation of Non‐Natural Prenyl Diphosphates: Access to New Fragrances and Probes
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202200211
Abstract: Two terpene cyclases were used as biocatalytic tool, namely, limonene synthase from Cannabis sativa (CLS) and 5‐epi‐aristolochene synthase (TEAS) from Nicotiana tabacum. They showed significant substrate flexibility towards non‐natural prenyl diphosphates to form novel terpenoids,… read more here.
Keywords: synthase; heterocyclic alkyne; natural prenyl; prenyl diphosphates ... See more keywords
Stabilization of Angiotensin-(1–7) by key substitution with a cyclic non-natural amino acid
Sign Up to like & getrecommendations! Published in 2017 at "Amino Acids"
DOI: 10.1007/s00726-017-2471-9
Abstract: Angiotensin-(1–7) [Ang-(1–7)], a heptapeptide hormone of the renin–angiotensin–aldosterone system, is a promising candidate as a treatment for cancer that reflects its anti-proliferative and anti-angiogenic properties. However, the peptide’s therapeutic potential is limited by the short… read more here.
Keywords: natural amino; amino; amino acid; cyclic non ... See more keywords
Novel synthetic approach to non-natural conformationally rigid spiro-linked amino acids
Sign Up to like & getrecommendations! Published in 2019 at "Russian Chemical Bulletin"
DOI: 10.1007/s11172-019-2452-0
Abstract: Abstract1-Aminospiro[2.3]hexane-1,5-dicarboxylic and 1-ammo-5-(ammomethyl)spiro[2.3]hexane-1-carboxylic acids, which are the conformationally rigid analogues of glutamic acid and lysine, respectively, were synthesized from 3-methylidenecyclobutanecarbonitrile. The synthetic route includes a catalytic [1+2]-cycloaddition of ethyl 2-diazo-2-nitroacetate to a double bond of… read more here.
Keywords: novel synthetic; non natural; spiro; approach non ... See more keywords
HPLC-based kinetics assay facilitates analysis of systems with multiple reaction products and thermal enzyme denaturation.
Sign Up to like & getrecommendations! Published in 2017 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2016.10.010
Abstract: Glucosinolates are plant secondary metabolites abundant in Brassica vegetables that are substrates for the enzyme myrosinase, a thioglucoside hydrolase. Enzyme-mediated hydrolysis of glucosinolates forms several organic products, including isothiocyanates (ITCs) that have been explored for… read more here.
Keywords: denaturation; multiple reaction; non natural; hplc based ... See more keywords
Systems biology based metabolic engineering for non-natural chemicals.
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology advances"
DOI: 10.1016/j.biotechadv.2019.04.001
Abstract: Production of chemicals in microorganisms is no longer restricted to products arising from native metabolic potential. In this review, we highlight the evolution of metabolic engineering studies, from the production of natural chemicals fermented from… read more here.
Keywords: production; metabolic engineering; biology; natural chemicals ... See more keywords
Structural Basis of Karrikin and Non-natural Strigolactone Perception in Physcomitrella patens.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.01.003
Abstract: In plants, strigolactones are perceived by the dual receptor-hydrolase DWARF14 (D14). D14 belongs to the superfamily of α/β hydrolases and is structurally similar to the karrikin receptor KARRIKIN INSENSITIVE 2 (KAI2). The moss Physcomitrella patens is… read more here.
Keywords: physcomitrella; natural strigolactone; physcomitrella patens; karrikin ... See more keywords
Using multi-scale spatial prioritization criteria to optimize non-natural mortality mitigation of target species
Sign Up to like & getrecommendations! Published in 2020 at "Global Ecology and Conservation"
DOI: 10.1016/j.gecco.2020.e01082
Abstract: Abstract Non-natural mortality is a major threat to animal conservation worldwide. Its origins are extremely diverse and include infrastructures that cause animal casualties. Its effects are widely felt and so prioritization criteria are necessary when… read more here.
Keywords: prioritization criteria; mortality; natural mortality; mortality mitigation ... See more keywords
Semisynthetic Isomers of Fucosylated Chondroitin Sulfate Polysaccharides with Fucosyl Branches at a Non-Natural Site.
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DOI: 10.1021/acs.biomac.1c01112
Abstract: The several interesting activities detected for fucosylated chondroitin sulfate (fCS) have fueled in the last years several efforts toward the obtainment of fCS oligosaccharides and low molecular weight (LMW) polysaccharides with a well-defined structure, in… read more here.
Keywords: sulfate; fucosylated chondroitin; semisynthetic isomers; chondroitin sulfate ... See more keywords
Tautomeric Equilibria of Nucleobases in the Hachimoji Expanded Genetic Alphabet.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of chemical theory and computation"
DOI: 10.1021/acs.jctc.9b01079
Abstract: Evolution has yielded biopolymers that are constructed from exactly four building blocks and are able to support Darwinian evolution. Synthetic biology aims to extend this alphabet, and we recently showed that 8-letter (hachimoji) DNA can… read more here.
Keywords: hachimoji; alphabet; expanded genetic; genetic alphabet ... See more keywords
Importance of Net Hydrophobicity in the Cellular Uptake of All-Hydrocarbon Stapled Peptides.
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DOI: 10.1021/acs.molpharmaceut.7b01130
Abstract: All-hydrocarbon stapled peptides make up a promising class of protein-protein interaction regulators; their potential therapeutic benefit arises because they have a high binding affinity and specificity for intracellular molecules. The cell permeation efficacy of these… read more here.
Keywords: cellular uptake; hydrocarbon stapled; stapled peptides; hydrophobicity ... See more keywords
Molecular Basis for the Substrate Promiscuity of Isopentenyl Phosphate Kinase from Candidatus methanomethylophilus alvus.
Sign Up to like & getrecommendations! Published in 2021 at "ACS chemical biology"
DOI: 10.1021/acschembio.1c00655
Abstract: Isopentenyl phosphate kinases (IPKs) catalyze the ATP-dependent phosphorylation of isopentenyl monophosphate (IP) to isopentenyl diphosphate (IPP) in the alternate mevalonate pathways of the archaea and plant cytoplasm. In recent years, IPKs have also been employed… read more here.
Keywords: candidatus methanomethylophilus; substrate promiscuity; isopentenyl phosphate; non natural ... See more keywords