Are the persistent effects of “gate control” stimulation on nociception a form of generalization of habituation that is endocannabinoid-dependent?
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Learning and Memory"
DOI: 10.1016/j.nlm.2018.09.001
Abstract: &NA; Repetitive activation of non‐nociceptive afferents is known to attenuate nociceptive signaling. However, the functional details of how this modulatory process operates are not understood and this has been a barrier in using such stimuli… read more here.
Keywords: nociception form; non nociceptive; stimulation; habituation ... See more keywords
Endocannabinoids Have Opposing Effects On Behavioral Responses To Nociceptive And Non-nociceptive Stimuli
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DOI: 10.1038/s41598-017-06114-1
Abstract: The endocannabinoid system is thought to modulate nociceptive signaling making it a potential therapeutic target for treating pain. However, there is evidence that endocannabinoids have both pro- and anti-nociceptive effects. In previous studies using Hirudo… read more here.
Keywords: effects behavioral; non nociceptive; behavioral responses; nociceptive stimuli ... See more keywords
Heterosynaptic long-term potentiation of non-nociceptive synapses requires endocannabinoids, NMDARs, CamKII, and PKCζ.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of neurophysiology"
DOI: 10.1152/jn.00494.2022
Abstract: Noxious stimuli or injury can trigger long-lasting sensitization to non-nociceptive stimuli (referred to as allodynia in mammals). Long-term potentiation (LTP) of nociceptive synapses has been shown to contribute to nociceptive sensitization (hyperalgesia) and there is… read more here.
Keywords: long term; non nociceptive; camkii pkc; term potentiation ... See more keywords
Non-nociceptive and nociceptive-like trigeminal Aβ-afferent neurons of rats: Distinct electrophysiological properties, mechanical and chemical sensitivity
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Pain"
DOI: 10.1177/17448069221148958
Abstract: The role of Aβ-afferents in somatosensory function is often oversimplified as low threshold mechanoreceptors (LTMRs) with large omission of Aβ-afferent involvement in nociception. Recently, we have characterized Aβ-afferent neurons which have large diameter somas in… read more here.
Keywords: sensitivity; afferent neurons; trigeminal afferent; electrophysiological properties ... See more keywords