Efficacy and safety of first-line checkpoint inhibitors-based treatments for non-oncogene-addicted non-small-cell lung cancer: a systematic review and meta-analysis.
Sign Up to like & getrecommendations! Published in 2022 at "ESMO open"
DOI: 10.1016/j.esmoop.2022.100465
Abstract: BACKGROUND Frontline immune checkpoint inhibitors (ICI)-based regimens in non-oncogene-addicted non-small-cell lung cancer (NSCLC) have been deeply investigated. To rank the available therapeutic options, we carried out a systematic review and Bayesian meta-analysis. METHODS A comprehensive… read more here.
Keywords: meta analysis; oncogene addicted; non oncogene; checkpoint inhibitors ... See more keywords
Anti-angiogenic agents in the age of resistance to immune checkpoint inhibitors: Do they have a role in non-oncogene-addicted non-small cell lung cancer?
Sign Up to like & getrecommendations! Published in 2020 at "Lung cancer"
DOI: 10.1016/j.lungcan.2020.04.009
Abstract: The introduction of licensed front-line immunotherapies has heralded a new era for the treatment of non-oncogene-addicted, advanced non-small cell lung cancer (NSCLC). Yet as with all evolutions in clinical management, changes in practice can outpace… read more here.
Keywords: evidence; oncogene addicted; lung cancer; non oncogene ... See more keywords
B-cell Lymphomas Exhibit a Non-Oncogene Addiction to SIRT3.
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DOI: 10.1158/2159-8290.cd-rw2019-093
Abstract: The metabolic enzyme SIRT3 is critical for B-cell lymphoma proliferation, survival, and tumor growth. read more here.
Keywords: exhibit non; lymphomas exhibit; cell; cell lymphomas ... See more keywords
Non-oncogene Addiction to SIRT5 in Acute Myeloid Leukemia.
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DOI: 10.1158/2643-3230.bcd-21-0026
Abstract: In this issue of Blood Cancer Discovery, Yan and colleagues discovered that mitochondrial deacylase, SIRT5, is required in AML cells to support mitochondrial oxidative phosphorylation, maintain redox homeostasis, and drive glutaminolysis. The new SIRT5 inhibitor,… read more here.
Keywords: myeloid leukemia; acute myeloid; oncogene addiction; addiction sirt5 ... See more keywords
Role of Radiosurgery and Stereotactic Ablative Radiotherapy for Oligometastatic Non-Oncogene Addicted NSCLC
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DOI: 10.3390/cancers14061465
Abstract: Simple Summary The definition and management of oligometastatic NSCLC have been incorporated into current guidelines on lung cancer, supporting the use of a definitive treatment with curative intent, including the focal ablation of all sites… read more here.
Keywords: non oncogene; stereotactic ablative; ablative radiotherapy; progression ... See more keywords
Non-Oncogene Addiction of KRAS-Mutant Cancers to IL-1β via Versican and Mononuclear IKKβ
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15061866
Abstract: Simple Summary Kirsten rat sarcoma virus (KRAS)-mutant cancers are frequent, metastatic, lethal, and largely undruggable. The aim of this study was to investigate the pathways through which KRAS-mutant cancers foster their growth, thereby unravelling novel… read more here.
Keywords: non oncogene; kras mutant; mutant cancers; addiction ... See more keywords