Mimicking Native Liver Lobule Microarchitecture In Vitro with Parenchymal and Non-parenchymal Cells Using 3D Bioprinting for Drug Toxicity and Drug Screening Applications.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c00312
Abstract: Bioengineering an in vitro liver model recapitulating the native liver microarchitecture consisting of parenchymal and non-parenchymal cells is crucial in achieving cellular crosstalk and hepatic metabolic functions for accurate hepatotoxicity prediction. Bioprinting holds the promise… read more here.
Keywords: liver; liver model; non parenchymal; parenchymal non ... See more keywords
Non-parenchymal TREM-2 protects the liver from immune-mediated hepatocellular damage
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DOI: 10.1136/gutjnl-2017-314107
Abstract: Objective Liver injury impacts hepatic inflammation in part via Toll-like receptor (TLR) signalling. Triggering receptor expressed on myeloid cells 2 (TREM-2) modulates TLR4-mediated inflammation in bone marrow (BM)-derived macrophages but its function in liver injury… read more here.
Keywords: inflammation; trem; non parenchymal; damage ... See more keywords
A Pathogenic Role of Non-Parenchymal Liver Cells in Alcohol-Associated Liver Disease of Infectious and Non-Infectious Origin
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DOI: 10.3390/biology12020255
Abstract: Simple Summary Over 70% of the liver comprises of parenchymal cells (named hepatocytes) and the rest 30% of cells are the non-parenchymal cells, which include macrophages (resident Kupffer cells), hepatic stellate cells, endothelial and immune… read more here.
Keywords: liver; associated liver; cells alcohol; alcohol associated ... See more keywords
Enrichment Methods for Murine Liver Non-Parenchymal Cells Differentially Affect Their Immunophenotype and Responsiveness towards Stimulation
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DOI: 10.3390/ijms23126543
Abstract: Hepatocytes comprise the majority of the liver and largely exert metabolic functions, whereas non-parenchymal cells (NPCs)—comprising Kupffer cells, dendritic cells and liver sinusoidal endothelial cells—control the immunological state within this organ. Here, we compared the… read more here.
Keywords: methods murine; murine liver; liver npcs; towards stimulation ... See more keywords
Antiviral Toll-like Receptor Signaling in Non-Parenchymal Liver Cells Is Restricted to TLR3
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DOI: 10.3390/v14020218
Abstract: The role of non-parenchymal liver cells as part of the hepatic, innate immune system in the defense against hepatotropic viruses is not well understood. Here, primary human Kupffer cells, liver sinusoidal endothelial cells and hepatic… read more here.
Keywords: toll like; non parenchymal; liver cells; parenchymal liver ... See more keywords
Interaction of non-parenchymal hepatocytes in the process of hepatic fibrosis
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DOI: 10.3892/mmr.2021.12003
Abstract: Hepatic fibrosis (HF) is the process of fibrous scar formation caused by chronic liver injury of different etiologies. Previous studies have hypothesized that the activation of hepatic stellate cells (HSCs) is the central process in… read more here.
Keywords: parenchymal hepatocytes; fibrosis; interaction; interaction non ... See more keywords