LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "non peptide" as a keyword



In Silico Drug Design: Non-peptide Mimetics for the Immunotherapy of Multiple Sclerosis.

Sign Up to like & get
recommendations! Published in 2018 at "Methods in molecular biology"

DOI: 10.1007/978-1-4939-8630-9_3

Abstract: Advances in theoretical chemistry have led to the development of various robust computational techniques employed in drug design. Pharmacophore modeling, molecular docking, and molecular dynamics (MD) simulations have been extensively applied, separately or in combination,… read more here.

Keywords: non peptide; drug design; drug; peptide mimetics ... See more keywords

Effect of Food Consumption on the Pharmacokinetics, Safety, and Tolerability of Once-Daily Orally Administered Orforglipron (LY3502970), a Non-peptide GLP-1 Receptor Agonist

Sign Up to like & get
recommendations! Published in 2024 at "Diabetes Therapy"

DOI: 10.1007/s13300-024-01554-1

Abstract: We assessed the effect of the prandial state on the pharmacokinetics, safety, and tolerability of single and multiple doses of orforglipron (LY3502970), an oral, non-peptide glucagon-like peptide 1 receptor agonist (GLP-1 RA), in two studies… read more here.

Keywords: study; safety tolerability; orforglipron ly3502970; safety ... See more keywords

Selective antagonism of CRF1 receptor by a substituted pyrimidine

Sign Up to like & get
recommendations! Published in 2019 at "Hormones"

DOI: 10.1007/s42000-019-00105-9

Abstract: The corticotrophin-releasing factor (CRF) and its type 1 receptor (CRF1R) regulate the hypothalamic-pituitary-adrenal axis, as well as other systems, thus playing a crucial role in the maintenance of homeostasis. Non-peptide CRF1R-selective antagonists exert therapeutic effects… read more here.

Keywords: crf1r; crf1r selective; non peptide; analog ... See more keywords

The non-peptide CRH1-antagonist CP-154,526 elicits a paradoxical route-dependent activation of the HPA axis

Sign Up to like & get
recommendations! Published in 2017 at "Neuroscience Letters"

DOI: 10.1016/j.neulet.2017.05.012

Abstract: The corticotropin-releasing hormone (CRH) plays an important role in mediating physiological response to stress and is thought to be involved in the development of various psychiatric disorders. In this paper, we compare the differences between… read more here.

Keywords: 154 526; non peptide; antagonist 154; peptide crh1 ... See more keywords

A non-peptide-based fluorescent probe capable of sensitively visualizing asparagine endopeptidase.

Sign Up to like & get
recommendations! Published in 2024 at "Chemical communications"

DOI: 10.1039/d3cc05419e

Abstract: The non-peptide-based fluorescent probe QMC11 is capable of specifically targeting asparagine endopeptidase (AEP) and imaging cellular endogenous AEP. The motion of the probe can be restricted by AEP to activate fluorescence while keeping a low… read more here.

Keywords: peptide based; asparagine endopeptidase; fluorescent probe; based fluorescent ... See more keywords
Photo from wikipedia

Discovery of non-peptide GLP-1r natural agonists for enhancing coronary safety in type 2 diabetes patients

Sign Up to like & get
recommendations! Published in 2024 at "Journal of Biomolecular Structure and Dynamics"

DOI: 10.1080/07391102.2023.2298734

Abstract: Abstract This study explores the computational discovery of non-peptide agonists targeting the Glucagon-Like Peptide-1 Receptor (GLP-1R) to enhance the safety of major coronary outcomes in individuals affected by Type 2 Diabetes. The objective is to… read more here.

Keywords: discovery non; type diabetes; non peptide; coronary safety ... See more keywords

Non-Peptide Agonists and Antagonists of the Prokineticin Receptors

Sign Up to like & get
recommendations! Published in 2022 at "Current Issues in Molecular Biology"

DOI: 10.3390/cimb44120431

Abstract: The prokineticin family comprises a group of secreted peptides that can be classified as chemokines based on their structural features and chemotactic and immunomodulatory functions. Prokineticins (PKs) bind with high affinity to two G protein-coupled… read more here.

Keywords: system; prokineticin receptors; agonists antagonists; antagonists prokineticin ... See more keywords

Non-Peptide Opioids Differ in Effects on Mu-Opioid (MOP) and Serotonin 1A (5-HT1A) Receptors Heterodimerization and Cellular Effectors (Ca2+, ERK1/2 and p38) Activation

Sign Up to like & get
recommendations! Published in 2022 at "Molecules"

DOI: 10.3390/molecules27072350

Abstract: The importance of the dynamic interplay between the opioid and the serotonin neuromodulatory systems in chronic pain is well recognized. In this study, we investigated whether these two signalling pathways can be integrated at the… read more here.

Keywords: peptide opioids; ht1a receptors; opioid mop; mop serotonin ... See more keywords