In Silico Drug Design: Non-peptide Mimetics for the Immunotherapy of Multiple Sclerosis.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8630-9_3
Abstract: Advances in theoretical chemistry have led to the development of various robust computational techniques employed in drug design. Pharmacophore modeling, molecular docking, and molecular dynamics (MD) simulations have been extensively applied, separately or in combination,… read more here.
Keywords: non peptide; drug design; drug; peptide mimetics ... See more keywords
Selective antagonism of CRF1 receptor by a substituted pyrimidine
Sign Up to like & getrecommendations! Published in 2019 at "Hormones"
DOI: 10.1007/s42000-019-00105-9
Abstract: The corticotrophin-releasing factor (CRF) and its type 1 receptor (CRF1R) regulate the hypothalamic-pituitary-adrenal axis, as well as other systems, thus playing a crucial role in the maintenance of homeostasis. Non-peptide CRF1R-selective antagonists exert therapeutic effects… read more here.
Keywords: crf1r; crf1r selective; non peptide; analog ... See more keywords
The non-peptide CRH1-antagonist CP-154,526 elicits a paradoxical route-dependent activation of the HPA axis
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2017.05.012
Abstract: The corticotropin-releasing hormone (CRH) plays an important role in mediating physiological response to stress and is thought to be involved in the development of various psychiatric disorders. In this paper, we compare the differences between… read more here.
Keywords: 154 526; non peptide; antagonist 154; peptide crh1 ... See more keywords
Non-Peptide Agonists and Antagonists of the Prokineticin Receptors
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DOI: 10.3390/cimb44120431
Abstract: The prokineticin family comprises a group of secreted peptides that can be classified as chemokines based on their structural features and chemotactic and immunomodulatory functions. Prokineticins (PKs) bind with high affinity to two G protein-coupled… read more here.
Keywords: system; prokineticin receptors; agonists antagonists; antagonists prokineticin ... See more keywords
Non-Peptide Opioids Differ in Effects on Mu-Opioid (MOP) and Serotonin 1A (5-HT1A) Receptors Heterodimerization and Cellular Effectors (Ca2+, ERK1/2 and p38) Activation
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27072350
Abstract: The importance of the dynamic interplay between the opioid and the serotonin neuromodulatory systems in chronic pain is well recognized. In this study, we investigated whether these two signalling pathways can be integrated at the… read more here.
Keywords: peptide opioids; ht1a receptors; opioid mop; mop serotonin ... See more keywords