Non-protein biologic therapeutics.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in biotechnology"
DOI: 10.1016/j.copbio.2017.12.014
Abstract: While the therapeutic biologics are dominated by therapeutic proteins, particularly monoclonal antibodies, a wide range of non-protein therapeutic biologics are rapidly gaining ground both in clinical studies and approved products. Many of these first-in-class therapies… read more here.
Keywords: non protein; oncology; protein biologic; biologic therapeutics ... See more keywords
Circadian analysis of the mouse retinal pigment epithelium transcriptome.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental eye research"
DOI: 10.1016/j.exer.2020.107988
Abstract: The presence of a phagocytic peak of photoreceptor outer segments by the retinal pigment epithelium (RPE) one or two hours after the onset of light has been reported for several diurnal and nocturnal species. This… read more here.
Keywords: protein; analysis; non protein; protein coding ... See more keywords
Non-protein amino acid derivatives of 25-methoxylprotopanaxadiol/25-hydroxyprotopanaxadioland their anti-tumour activity evaluation
Sign Up to like & getrecommendations! Published in 2018 at "Steroids"
DOI: 10.1016/j.steroids.2017.11.003
Abstract: HIGHLIGHTS25 novel protopanaxadiol analogs have been synthesized.Combine with non‐protein amino acids moiety exhibited anti‐canceractivities.Compounds 9 and 14 exhibited strong biological activity on cancer celllines. ABSTRACT As active components of ginseng, 25‐methoxylprotopanaxadiol and 25‐hydroxyprotopanaxadiol exhibited an… read more here.
Keywords: non protein; protein amino; activity; anti tumour ... See more keywords
Analysis of the small non-protein-coding RNA profile of mouse spermatozoa reveals specific enrichment of piRNAs within mature spermatozoa
Sign Up to like & getrecommendations! Published in 2017 at "RNA Biology"
DOI: 10.1080/15476286.2017.1356569
Abstract: ABSTRACT Post-testicular sperm maturation and storage within the epididymis is a key determinant of gamete quality and fertilization competence. Here we demonstrate that mouse spermatozoa possess a complex small non-protein-coding RNA (sRNA) profile, the composition… read more here.
Keywords: spermatozoa; non protein; small non; mouse spermatozoa ... See more keywords
Long intergenic non-protein coding RNA 662 accelerates the progression of gastric cancer through up-regulating centrosomal protein 55 by sponging microRNA-195-5p
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2021.2023978
Abstract: ABSTRACT Long non-coding RNAs (lncRNAs) are important players in regulating diverse human diseases, including cancers. Nonetheless, the function of long intergenic non-protein coding RNA 662 (LINC00662) in gastric cancer (GC) carcinogenesis and progression remains to… read more here.
Keywords: non protein; long intergenic; cep55; intergenic non ... See more keywords
Long intergenic non-protein coding RNA 115 (LINC00115) aggravates retinoblastoma progression by targeting microRNA miR-489-3p that downregulates 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (PFKFB2)
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2037362
Abstract: ABSTRACT Long non-coding RNAs (lncRNAs) are key regulators of cancer. However, the role of long intergenic non-protein coding RNA 115 (LINC00115) in the regulation of retinoblastoma (RB) has not yet been studied. The expression levels… read more here.
Keywords: intergenic non; non protein; long intergenic; pfkfb2 ... See more keywords
Testing the protein-leverage hypothesis using population surveillance data
Sign Up to like & getrecommendations! Published in 2022 at "Royal Society Open Science"
DOI: 10.1098/rsos.220756
Abstract: It is hypothesized that humans exhibit ‘protein leverage’ (PL), whereby regulation of absolute protein intake results in the over-consumption of non-protein food on low percentage protein diets. Testing for PL using dietary surveillance data involves… read more here.
Keywords: non protein; surveillance data; protein intake; protein leverage ... See more keywords
Effect of p‐coumaric acid on the erectogenic enzyme activities and non‐protein thiol level in the penile tissue of normal and doxorubicin‐induced oxidative stress male rat
Sign Up to like & getrecommendations! Published in 2019 at "Andrologia"
DOI: 10.1111/and.13281
Abstract: This study investigated effect of p‐coumaric acid (PCA) on erectogenic enzyme activity and non‐protein thiol level in the penile tissue of normal and doxorubicin (DOX)‐induced oxidative stress male rat. Sixty‐four (64) adult male rats weighing… read more here.
Keywords: protein thiol; penile tissue; thiol level; non protein ... See more keywords
Role of inhibitory B cell co‐receptors in B cell self‐tolerance to non‐protein antigens *
Sign Up to like & getrecommendations! Published in 2022 at "Immunological Reviews"
DOI: 10.1111/imr.13059
Abstract: Antibodies to non‐protein antigens such as nucleic acids, polysaccharides, and glycolipids play important roles in both host defense against microbes and development of autoimmune diseases. Although non‐protein antigens are not recognized by T cells, antibody… read more here.
Keywords: cell; non protein; protein antigens; tolerance ... See more keywords
Role of the Long Intergenic Non-Protein-Coding RNA 1278/miR-185-5p/Cystatin SN Axis in Laryngeal Cancer Cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Oncology"
DOI: 10.1155/2022/6406943
Abstract: Laryngeal cancer accounts for 25%–30% of tumors in the head and neck. Cystatin SN (CST1) was revealed to show upregulated expression in this cancer, while its functions and upstream pathway remain unknown and need investigation.… read more here.
Keywords: non protein; laryngeal cancer; long intergenic; intergenic non ... See more keywords
Significance of Single-Nucleotide Variants in Long Intergenic Non-protein Coding RNAs
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.00347
Abstract: Single-nucleotide variants (SNVs) are the most common genetic variants and universally present in the human genome. Genome-wide association studies (GWASs) have identified a great number of disease or trait-associated variants, many of which are located… read more here.
Keywords: intergenic non; long intergenic; coding rnas; single nucleotide ... See more keywords