Shear force modulates the activity of acid-sensing ion channels at low pH or in the presence of non-proton ligands
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-43097-7
Abstract: Acid-sensing ion channels (ASICs) belong to the degenerin/epithelial sodium channel protein family that form mechanosensitive ion channels. Evidence as to whether or not ASICs activity is directly modulated by mechanical force is lacking. Human ASICs… read more here.
Keywords: ion channels; proton ligands; non proton; force ... See more keywords
Signaling Pathways in Proton and Non-proton ASIC1a Activation
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2021.735414
Abstract: Acid-sensing ion channels (ASICs) regulate synaptic activities and play important roles in neurodegenerative diseases as well as pain conditions. Classically, ASICs are described as transiently activated by a reduced pH, followed by desensitization; the activation… read more here.
Keywords: signaling pathways; asic1a; proton; activation ... See more keywords