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   Articles with "non replicating" as a keyword



Assessing the propensity of TB clinical isolates to form viable but non-replicating subpopulations

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recommendations! Published in 2024 at "Scientific Reports"

DOI: 10.1038/s41598-024-79389-w

Abstract: Current tuberculosis (TB) treatment is typically effective against drug-susceptible Mycobacterium tuberculosis, but can fail due to acquired drug resistance or phenotypic resistance. M. tuberculosis persisters, a subpopulation of viable but non-replicating (VBNR) antibiotic-tolerant bacteria, are… read more here.

Keywords: treatment; clinical isolates; non replicating; treatment outcomes ... See more keywords

Cholesterol-dependent activity of dapsone against non-replicating persistent mycobacteria.

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recommendations! Published in 2022 at "Microbiology"

DOI: 10.1099/mic.0.001279

Abstract: One-third of the world's population is estimated to be latently infected with Mycobacterium tuberculosis. This reservoir of bacteria is largely resistant to antimicrobial treatment that often only targets actively replicating mycobacteria, with current treatment for… read more here.

Keywords: non replicating; dapsone; activity; cholesterol dependent ... See more keywords

Single immunizations of self-amplifying or non-replicating mRNA-LNP vaccines control HPV-associated tumors in mice

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recommendations! Published in 2023 at "Science Translational Medicine"

DOI: 10.1126/scitranslmed.abn3464

Abstract: As mRNA vaccines have proved to be very successful in battling the coronavirus disease 2019 (COVID-19) pandemic, this new modality has attracted widespread interest for the development of potent vaccines against other infectious diseases and… read more here.

Keywords: self amplifying; replicating mrna; mrna vaccines; hpv ... See more keywords

Novel Screen to Assess Bactericidal Activity of Compounds Against Non-replicating Mycobacterium abscessus

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recommendations! Published in 2018 at "Frontiers in Microbiology"

DOI: 10.3389/fmicb.2018.02417

Abstract: Mycobacterium abscessus infections are increasing worldwide. Current drug regimens are largely ineffective, yet the current development pipeline for M. abscessus is alarmingly sparse. Traditional discovery efforts for M. abscessus assess the capability of a new… read more here.

Keywords: abscessus; novel screen; non replicating; bactericidal activity ... See more keywords

Latent Tuberculosis: A Promising New Compound to Treat Non-Replicating and Intramacrophagic Mycobacteria

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recommendations! Published in 2022 at "Biomedicines"

DOI: 10.3390/biomedicines10102398

Abstract: As a biologic reservoir of Mycobacterium tuberculosis (M. tb), one-quarter of the world population is infected with the well-known latent tuberculosis (LTBI). About 5–10% of LTBI patients will progress to active disease in the first… read more here.

Keywords: tuberculosis; treat; promising new; tuberculosis promising ... See more keywords