Non‐sedating antihistamines block G‐protein‐gated inwardly rectifying K+ channels
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DOI: 10.1111/bph.14717
Abstract: A second‐generation antihistamine, terfenadine, is known to induce arrhythmia by blocking hERG channels. In this study, we have shown that terfenadine also inhibits the activity of G‐protein‐gated inwardly rectifying K+ (GIRK) channels, which regulate the… read more here.
Keywords: protein gated; sedating antihistamines; gated inwardly; inwardly rectifying ... See more keywords
Non-sedating benzodiazepines cause paralysis and tissue damage in the parasitic blood fluke Schistosoma mansoni
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0007826
Abstract: Parasitic flatworm infections (e.g. tapeworms and fluke worms) are treated by a limited number of drugs. In most cases, control is reliant upon praziquantel (PZQ) monotherapy. However, PZQ is ineffective against sexually immature parasites, and… read more here.
Keywords: sedating benzodiazepines; benzodiazepines cause; schistosoma mansoni; cause paralysis ... See more keywords