The thymus and the science of self
Sign Up to like & getrecommendations! Published in 2021 at "Seminars in Immunopathology"
DOI: 10.1007/s00281-020-00831-y
Abstract: The conventional perception asserts that immunology is the science of ‘discrimination’ between self and non-self. This concept is however no longer tenable as effector cells of the adaptive immune system are first conditioned to be… read more here.
Keywords: self; thymus science; non self; immunology ... See more keywords
Phylogenetic and Expression Analyses of Cullin Family Members Unveil the Role of PbCUL1.C1 in Pollen Tube Growth Underlying Non-self S-RNase in Pear
Sign Up to like & getrecommendations! Published in 2020 at "Plant Molecular Biology Reporter"
DOI: 10.1007/s11105-020-01221-2
Abstract: Cullin ( CUL ) gene family organizes the largest class of RING E3 ligases which play crucial roles in the ubiquitin-proteasome system to affect plant physiological activities. However, little is known about the CUL genes… read more here.
Keywords: self rnase; pbcul1; non self; pollen ... See more keywords
Some fixed point theorems for non-self mappings of contractive type with applications to endpoint theory
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Fixed Point Theory and Applications"
DOI: 10.1007/s11784-017-0428-y
Abstract: In this paper, in the setting of complete metric spaces we establish some fixed point theorems for non-self mappings of contractive type satisfying either the Reich–Zaslavski property or the approximate fixed point property. As applications,… read more here.
Keywords: theorems non; point; non self; point theorems ... See more keywords
Powerful Substances Because of Powerless Powers
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Philosophical Association"
DOI: 10.1017/apa.2019.18
Abstract: Abstract I argue that the debate between proponents of substance causation and proponents of causation by powers, as to whether substances or their powers are causes, hinges on whether or not powers (as properties) are… read more here.
Keywords: substance causation; exemplifying properties; causation; self exemplifying ... See more keywords
Myeloid memory to non-self
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Immunology"
DOI: 10.1038/s41577-020-0375-5
Abstract: Myeloid cells acquire memory to previously encountered MHC alloantigens, showing antigen specificity akin to adaptive immune memory. This myeloid cell memory response mediates allograft rejection. read more here.
Keywords: memory non; myeloid memory; non self; memory ... See more keywords
Knowing me, knowing you: Self and non-self recognition in plant immunity.
Sign Up to like & getrecommendations! Published in 2022 at "Essays in biochemistry"
DOI: 10.1042/ebc20210095
Abstract: Perception of non-self molecules known as microbe-associated molecular patterns (MAMPs) by host pattern recognition receptors (PRRs) activates plant pattern-triggered immunity (PTI). Pathogen infections often trigger the release of modified-self molecules, termed damage- or danger-associated molecular… read more here.
Keywords: recognition; non self; immunity; plant ... See more keywords
'Non-self' Mutation: Double-stranded RNA elicits antiviral pathogenic response in a Drosophila model of expanded CAG repeat neurodegenerative diseases.
Sign Up to like & getrecommendations! Published in 2019 at "Human molecular genetics"
DOI: 10.1093/hmg/ddz096
Abstract: Inflammation is activated prior to symptoms in neurodegenerative diseases, providing a plausible pathogenic mechanism. Indeed genetic and pharmacological ablation studies in animal models of several neurodegenerative diseases demonstrate that inflammation is required for pathology. However,… read more here.
Keywords: repeat; rna; neurodegenerative diseases; pathology ... See more keywords
Maintenance Policies for a Deteriorating System Subject to Non-Self-Announcing Failures
Sign Up to like & getrecommendations! Published in 2017 at "IEEE Transactions on Reliability"
DOI: 10.1109/tr.2016.2639358
Abstract: In this study, we comparatively evaluate various maintenance policies for systems subject to continuous-time Markovian deterioration, which may result in non-self-announcing failures. The decision maker inspects the system periodically at the decision epochs, identifies the… read more here.
Keywords: self announcing; system; maintenance; maintenance policies ... See more keywords
Novel insights into non‐HLA alloimmunity in kidney transplantation
Sign Up to like & getrecommendations! Published in 2019 at "Transplant International"
DOI: 10.1111/tri.13546
Abstract: Recognition of non‐self structures on donor cells represents the main immunological barrier in solid organ transplantation. The human leukocyte antigens (HLA) are considered the most important non‐self (allo)antigens in transplantation. Long‐term graft attrition is mainly… read more here.
Keywords: insights non; non hla; hla alloimmunity; novel insights ... See more keywords
Cyclophosphamide eradicates murine immunogenic tumor coding for a non-self-antigen and induces antitumor immunity
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Immunopathology and Pharmacology"
DOI: 10.1177/2058738418796591
Abstract: Although the majority of cancers respond to chemotherapy, most cancer types relapse, at least in part, due to the poor immunogenicity of most tumor. We have reported before that treatment of tumor bearing mice with… read more here.
Keywords: immunogenic tumor; non self; self antigen; mice ... See more keywords
Integration of Self and Non-self Recognition Modulates Asexual Cell-to-Cell Communication in Neurospora crassa
Sign Up to like & getrecommendations! Published in 2019 at "Genetics"
DOI: 10.1534/genetics.118.301780
Abstract: Cells cooperate, compete, and are attacked in nature, driving the evolution of mechanisms for recognizing self versus non-self. Filamentous fungal cells cooperate to form an interconnected colony while competing with genetically dissimilar colonies... Cells rarely… read more here.
Keywords: cell cell; non self; fusion; cell ... See more keywords