New insights into no-go, non-stop and nonsense-mediated mRNA decay complexes.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2020.06.011
Abstract: Eukaryotes possess a variety of translational control mechanisms which function in the surveillance of mRNAs, discriminating between normal and aberrant translation elongation and termination, triggering mRNA decay. The three major evolutionarily conserved eukaryotic pathways are… read more here.
Keywords: non stop; mrna decay; mediated mrna; nonsense mediated ... See more keywords
The non-stop waste of water
Sign Up to like & getrecommendations! Published in 2019 at "Nature"
DOI: 10.1038/d41586-019-00214-w
Abstract: Margaret Catley-Carlson reflects on millennia of resource mismanagement.Margaret Catley-Carlson reflects on millennia of resource mismanagement. read more here.
Keywords: non stop; waste water; stop waste;
The ribosome-associated quality control pathway supports survival in the absence of non-stop ribosome rescue factors
Sign Up to like & getrecommendations! Published in 2024 at "mBio"
DOI: 10.1128/mbio.02322-24
Abstract: ABSTRACT In bacteria, if a ribosome translates an mRNA lacking a stop codon it becomes stalled at the 3′ end of the message. These ribosomes must be rescued by trans-translation or the alternative rescue factors… read more here.
Keywords: ribosome rescue; quality control; trans translation; ribosome ... See more keywords
Running for Your Life: Metabolic Effects of a 160.9/230 km Non-Stop Ultramarathon Race on Body Composition, Inflammation, Heart Function, and Nutritional Parameters
Sign Up to like & getrecommendations! Published in 2022 at "Metabolites"
DOI: 10.3390/metabo12111138
Abstract: Moderate endurance exercise leads to an improvement in cardiovascular performance, stress resilience, and blood function. However, the influence of chronic endurance exercise over several hours or days is still largely unclear. We examined the influence… read more here.
Keywords: function; 160 230; body composition; race ... See more keywords
Ataxin-7 and Non-stop coordinate SCAR protein levels, subcellular localization, and actin cytoskeleton organization
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.49677
Abstract: Atxn7, a subunit of SAGA chromatin remodeling complex, is subject to polyglutamine expansion at the amino terminus, causing spinocerebellar ataxia type 7 (SCA7), a progressive retinal and neurodegenerative disease. Within SAGA, the Atxn7 amino terminus… read more here.
Keywords: non stop; protein levels; actin cytoskeleton; subcellular localization ... See more keywords