Halogenated boroxine increases propensity to apoptosis in leukemia (UT‐7) but not non‐tumor cells in vitro
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13522
Abstract: A hallmark of the development of solid and hematological malignancies is the dysregulation of apoptosis, which leads to an imbalance between cell proliferation, cell survival and death. Halogenated boroxine [K2(B3O3F4OH)] (HB) is a derivative of… read more here.
Keywords: apoptosis; tumor cells; non tumor; tumor ... See more keywords
Targeting The Tumor Microenvironment in Lymphomas: Emerging Biological Insights and Therapeutic Strategies
Sign Up to like & getrecommendations! Published in 2022 at "Current Oncology Reports"
DOI: 10.1007/s11912-022-01250-y
Abstract: This review aims to discuss recent advances in elucidating the tumor microenvironment (TME) in B lymphomas and resultant novel therapeutic development. While tumor morphology, immunophenotype, and molecular profile are established factors that predict outcome and… read more here.
Keywords: non tumor; tumor cells; tumor microenvironment; lymphomas ... See more keywords
Non-tumor cell IDO1 predominantly contributes to enzyme activity and response to CTLA-4/PD-L1 inhibition in mouse glioblastoma
Sign Up to like & getrecommendations! Published in 2017 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2017.01.022
Abstract: Glioblastoma (GBM) is the most common malignant brain tumor in adults with a median survival of 14.6months. A contributing factor to GBM aggressiveness is the intratumoral expression of the potently immunosuppressive enzyme, indoleamine 2,3 dioxygenase… read more here.
Keywords: cell ido1; non tumor; tumor cell; cell ... See more keywords
Role of ceRNAs in non-tumor female reproductive diseases
Sign Up to like & getrecommendations! Published in 2022 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioac200
Abstract: Abstract The molecular mechanism of non-tumor female reproductive diseases is complicated and needs to be further elucidated. Recently, increasing evidence indicates that non-coding RNAs(ncRNAs) which are extremely rich in the female reproductive system are crucial… read more here.
Keywords: role cernas; reproductive diseases; female reproductive; non tumor ... See more keywords
Clusterin expression in non-tumor tissue in patients with resectable hepatocellular carcinoma related with post-resectional survival.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Chinese Medical Association"
DOI: 10.1097/jcma.0000000000000195
Abstract: BACKGROUND Surgical resection offers an effective treatment for patients with hepatocellular carcinoma (HCC); however, it has high tumor recurrence rate. Clusterin is a highly conserved glycoprotein that enhances cell aggregation in vitro. It is upregulated… read more here.
Keywords: non tumor; tissue; clusterin expression; tumor ... See more keywords
Abstract 3135: Validation of a bioinformatic model for classifying non-tumor variants in a cell-free DNA liquid biopsy assay
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3135
Abstract: Background: Liquid biopsy has been established as a powerful, non-invasive means to profile tumors in and identify clinically relevant variants. However, the presence of clonal hematopoiesis (CH) variants, or biological noise, due to aging or… read more here.
Keywords: validation; tumor variants; non tumor; liquid biopsy ... See more keywords
Identification of cancer-related genes FGFR2 and CEBPB in choledochal cyst via RNA sequencing of patient-derived liver organoids
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0283737
Abstract: Background Choledochal cysts (CC) are congenital bile duct anomalies with 6–30% risk for developing bile duct cancer. However, the molecular mechanisms underlying cancer risk of CC are unknown. We sought to identify the gene expression… read more here.
Keywords: fgfr2 cebpb; liver; non tumor; tumor ... See more keywords
Essential amino acids as diagnostic biomarkers of hepatocellular carcinoma based on metabolic analysis.
Sign Up to like & getrecommendations! Published in 2022 at "Oncotarget"
DOI: 10.18632/oncotarget.28306
Abstract: Metabolomics, defined as the comprehensive identification of all small metabolites in a biological sample, has the power to shed light on phenotypic changes associated with various diseases, including cancer. To discover potential metabolomic biomarkers of… read more here.
Keywords: amino acids; hepatocellular carcinoma; biomarkers hepatocellular; essential amino ... See more keywords
miR-223 and Stathmin-1 Expression in Non-tumor Liver Tissue of Patients with Hepatocellular Carcinoma.
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DOI: 10.21873/anticanres.12033
Abstract: AIM Overexpression of stathmin (STMN1) has been reported for several tumor entities. STMN1 expression correlated with the detection of mutant p53, also suggesting loss-of-function-dependent mechanisms for its accumulation in hepatocellular carcinoma (HCC) cells. On the… read more here.
Keywords: high low; non tumor; expression; mir 223 ... See more keywords
Multiomics Analysis Reveals the Prognostic Non-tumor Cell Landscape in Glioblastoma Niches
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2021.741325
Abstract: A comprehensive characterization of non-tumor cells in the niches of primary glioblastoma is not fully established yet. This study aims to present an overview of non-malignant cells in the complex microenvironment of glioblastoma with detailed… read more here.
Keywords: glioblastoma; response; non tumor; tumor cell ... See more keywords
CircRNA ITCH: Insight Into Its Role and Clinical Application Prospect in Tumor and Non-Tumor Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.927541
Abstract: CircRNA E3 ubiquitin protein ligase (ITCH) (circRNA ITCH, circ-ITCH), a stable closed-loop RNA derived from the 20q11.22 region of chromosome 20, is a new circRNA discovered in the cytoplasm in recent decades. Studies have shown… read more here.
Keywords: circrna itch; itch; tumor non; non tumor ... See more keywords