Immunogenicity and safety of 11- and 12-valent pneumococcal non-typeable Haemophilus influenzae protein D-conjugate vaccines (11vPHiD-CV, 12vPHiD-CV) in infants: Results from a phase II, randomised, multicentre study.
Sign Up to like & getrecommendations! Published in 2019 at "Vaccine"
DOI: 10.1016/j.vaccine.2018.07.023
Abstract: BACKGROUND We assessed 2 investigational 11- and 12-valent vaccines, containing capsular polysaccharides of 10 serotypes as in the pneumococcal non-typeable Haemophilus influenzae protein D-conjugate vaccine (PHiD-CV) and CRM197-conjugated capsular polysaccharides of serotypes 19A (11-valent) or… read more here.
Keywords: phid; pneumococcal non; booster; non ... See more keywords
Non-typeable Haemophilus influenzae isolates from patients with chronic obstructive pulmonary disease contain new phase-variable modA methyltransferase alleles controlling phasevarions
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DOI: 10.1038/s41598-019-52429-6
Abstract: Phasevarions (phase-variable regulons) are emerging as an important area of bacterial gene regulation. Many bacterial pathogens contain phasevarions, with gene expression controlled by the phase-variable expression of DNA methyltransferases via epigenetic mechanisms. Non-typeable Haemophilus influenzae… read more here.
Keywords: haemophilus influenzae; non typeable; phase variable; typeable haemophilus ... See more keywords
Examination of phase-variable haemoglobin–haptoglobin binding proteins in non-typeable Haemophilus influenzae reveals a diverse distribution of multiple variants
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DOI: 10.1093/femsle/fnac064
Abstract: Abstract Non-typeable Haemophilus influenzae (NTHi) is a major human pathogen for which there is no globally licensed vaccine. NTHi has a strict growth requirement for iron and encodes several systems to scavenge elemental iron and… read more here.
Keywords: typeable haemophilus; haemophilus influenzae; binding proteins; non typeable ... See more keywords
D-methionine interferes with non-typeable Haemophilus influenzae peptidoglycan synthesis during growth and biofilm formation.
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DOI: 10.1099/mic.0.000491
Abstract: Non-typeable Haemophilus influenzae (NTHi) is an opportunistic pathogen that plays a major role in a number of respiratory tract infections, including otitis media, cystic fibrosis and chronic obstructive pulmonary disease. Biofilm formation has been implicated… read more here.
Keywords: methionine; treatment; biofilm formation; formation ... See more keywords
Antimicrobial activity of a novel bioengineered honey against non-typeable Haemophilus influenzae biofilms: an in vitro study
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Pathology"
DOI: 10.1136/jclinpath-2017-204901
Abstract: The opportunistic pathogen non-typeable Haemophilus influenzae (NTHi) plays an important role in many chronic respiratory diseases including otitis media, chronic rhinosinusitis, cystic fibrosis and chronic obstructive pulmonary disease. Biofilm formation has been implicated in NTHi… read more here.
Keywords: typeable haemophilus; haemophilus influenzae; non typeable;
Primary ciliary dyskinesia exhibits dysregulated epithelial responses to non-typeable Haemophilus influenzae
Sign Up to like & getrecommendations! Published in 2017 at "European Respiratory Journal"
DOI: 10.1183/1393003.congress-2017.oa4628
Abstract: Background: PCD is an inherited heterogenous disorder of impaired mucociliary clearance. Early colonisation of the lower airways with non-typeable Haemophilus influenzae (NTHi) is common. Chronic inflammation and recurrent infections inevitably lead to irreversible bronchiectasis. It… read more here.
Keywords: haemophilus influenzae; non typeable; pcd; typeable haemophilus ... See more keywords
Non-typeable Haemophilus influenzae infection of ciliated epithelium from healthy and chronic obstructive pulmonary disease donors
Sign Up to like & getrecommendations! Published in 2018 at "European Respiratory Journal"
DOI: 10.1183/13993003.congress-2018.pa5300
Abstract: Background: Non-typeable Haemophilus influenzae (NTHi) is strongly associated with exacerbation of Chronic Obstructive Pulmonary Disease (COPD). Little is known about initial NTHi-host interactions and how this leads to colonisation. Therefore, we investigated early NTHi interaction… read more here.
Keywords: chronic obstructive; haemophilus influenzae; microscopy; obstructive pulmonary ... See more keywords
Non-typeable Haemophilus influenzae airways infection: the next treatable trait in asthma?
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DOI: 10.1183/16000617.0008-2022
Abstract: Asthma is a complex, heterogeneous condition that affects over 350 million people globally. It is characterised by bronchial hyperreactivity and airways inflammation. A subset display marked airway neutrophilia, associated with worse lung function, higher morbidity… read more here.
Keywords: non typeable; infection; asthma; haemophilus influenzae ... See more keywords
Effects of repeated infections with non-typeable Haemophilus influenzae on lung in vitamin D deficient and smoking mice
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DOI: 10.1186/s12931-022-01962-6
Abstract: Background In chronic obstructive pulmonary disease (COPD), exacerbations cause acute inflammatory flare-ups and increase the risk for hospitalization and mortality. Exacerbations are common in all disease stages and are often caused by bacterial infections e.g.,… read more here.
Keywords: lung; infections non; copd; anti nthi ... See more keywords
Molecular Identification of Invasive Non-typeable Group B Streptococcus Isolates From Denmark (2015 to 2017)
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DOI: 10.3389/fcimb.2021.571901
Abstract: The number of invasive Streptococcus agalactiae (GBS) non-typeable (NT) isolates in Denmark received since 1999 has in general accounted for 10% of all invasive GBS isolates. We present data on 55 clinical NT isolates based… read more here.
Keywords: group; 2015 2017; non typeable; streptococcus ... See more keywords
Inflammatory Responses to Non-Typeable Haemophilus influenzae Clinical Isolates from Invasive and Non-Invasive Infections
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DOI: 10.3390/pathogens14030210
Abstract: Non-typeable Haemophilus influenzae (NTHi) is often asymptomatically carried in the upper airways but can cause a wide spectrum of disease conditions, from local respiratory tract infections to invasive disease such as sepsis or meningitis. The… read more here.
Keywords: disease; non typeable; typeable haemophilus; inflammatory responses ... See more keywords