Classifying BRAF alterations in cancer: new rational therapeutic strategies for actionable mutations
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/s41388-018-0171-x
Abstract: The RAS–RAF–MEK–ERK signaling cascade is among the most frequently mutated pathways in human cancer. Approximately 50% of melanoma patients possess a druggable hotspot V600E/K mutation in the BRAF protein kinase. FDA-approved combination therapies of BRAF… read more here.
Keywords: braf alterations; braf; cancer; non v600 ... See more keywords
Trametinib Activity in Patients with Solid Tumors and Lymphomas Harboring BRAF Non-V600 Mutations or Fusions: Results from NCI-MATCH (EAY131)
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-19-3443
Abstract: Purpose: Substantial preclinical evidence and case reports suggest that MEK inhibition is an active approach in tumors with BRAF mutations outside the V600 locus, and in BRAF fusions. Thus, Subprotocol R of the NCI-MATCH study… read more here.
Keywords: braf; solid tumors; non v600; nci match ... See more keywords
Non-V600 BRAF mutations in advanced malignancies: Prevalence and survival impact.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.12100
Abstract: 12100Background: BRAF mutations that occur outside of codon 600, non-V600 BRAF (non-V600BRAF), have been detected in various types of tumors. Prevalence, and prognostic impact remain underestimated... read more here.
Keywords: v600 braf; non v600; impact; braf mutations ... See more keywords
Clinical, Pathological and Prognostic Features of Rare BRAF Mutations in Metastatic Colorectal Cancer (mCRC): A Bi-Institutional Retrospective Analysis (REBUS Study)
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DOI: 10.3390/cancers13092098
Abstract: Simple Summary Somatic BRAF mutations occur in approximately 10% of metastatic colorectal cancers (mCRCs) and, according to the involved codon, are classified as V600E and in non-V600, accounting for 80% and 20%, respectively. Being the… read more here.
Keywords: mcrcs; non v600; braf non; braf ... See more keywords
Genomic Landscape, Clinical Features and Outcomes of Non-Small Cell Lung Cancer Patients Harboring BRAF Alterations of Distinct Functional Classes
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DOI: 10.3390/cancers14143472
Abstract: Simple Summary Non-small cell lung cancer (NSCLC) patients harboring BRAF non-V600 alterations constitute a heterogeneous and poorly studied population orphan of targeted therapies. We conducted a systematic review to detect all BRAF alterations of defined… read more here.
Keywords: cancer; braf alterations; nsclc patients; class ... See more keywords