Optimal model‐based control of non‐viral siRNA delivery
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26596
Abstract: Further quantitative understanding of the biological effects and mechanisms involved in cellular and intracellular delivery of nucleic acid materials is required to produce clinical applications of gene therapy. Several modeling approaches have been used in… read more here.
Keywords: model based; non viral; viral sirna; delivery ... See more keywords
Comparative efficacy and safety of atezolizumab and bevacizumab between hepatocellular carcinoma patients with viral and non‐viral infection: A Japanese multicenter observational study
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5337
Abstract: This study compared the efficacy and safety of atezolizumab and bevacizumab (Atez/Bev) in patients with viral and non‐viral infection in clinical settings. read more here.
Keywords: non viral; safety atezolizumab; atezolizumab bevacizumab; efficacy safety ... See more keywords
A global perspective of pediatric non-viral keratitis: literature review
Sign Up to like & getrecommendations! Published in 2020 at "International Ophthalmology"
DOI: 10.1007/s10792-020-01451-z
Abstract: Purpose This focused review aims to explore pediatric non-viral keratitis and to compare associated risk factors, etiologies, antibiotic susceptibilities, empiric treatments and outcomes. Methods The authors performed a literature research for articles, published on PubMed,… read more here.
Keywords: non viral; viral keratitis; risk factors; review ... See more keywords
Scaffold-mediated non-viral delivery platform for CRISPR/Cas9-based genome editing.
Sign Up to like & getrecommendations! Published in 2019 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2019.04.020
Abstract: Genome editing, especially via the simple and versatile type II CRISPR/Cas9 system, offers an effective avenue to precisely control cell fate, an important aspect of tissue regeneration. Unfortunately, most CRISPR/Cas9 non-viral delivery strategies only utilise… read more here.
Keywords: genome editing; non viral; crispr cas9; cas9 sgrna ... See more keywords
Advances in mRNA non-viral delivery approaches.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced drug delivery reviews"
DOI: 10.1016/j.addr.2021.113930
Abstract: Messenger RNAs (mRNAs) present a great potential as therapeutics for the treatment and prevention of a wide range of human pathologies, allowing for protein replacement, vaccination, cancer immunotherapy, and genomic engineering. Despite advances in the… read more here.
Keywords: non viral; delivery approaches; advances mrna; delivery ... See more keywords
Effects of spinal non-viral interleukin-10 gene therapy formulated with d-mannose in neuropathic interleukin-10 deficient mice: Behavioral characterization, mRNA and protein analysis in pain relevant tissues
Sign Up to like & getrecommendations! Published in 2018 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2017.11.004
Abstract: Studies show that spinal (intrathecal; i.t.) interleukin-10 (IL-10) gene therapy reverses neuropathic pain in animal models, and co-administration with the mannose receptor (MR; CD206) ligand d-mannose (DM) greatly improves therapeutic efficacy. However, the actions of… read more here.
Keywords: non viral; gene therapy; neuropathic pain; therapy ... See more keywords
Non-viral delivery systems for CRISPR/Cas9-based genome editing: Challenges and opportunities.
Sign Up to like & getrecommendations! Published in 2018 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2018.04.031
Abstract: In recent years, CRISPR (clustered regularly interspaced short palindromic repeat)/Cas (CRISPR-associated) genome editing systems have become one of the most robust platforms in basic biomedical research and therapeutic applications. To date, efficient in vivo delivery of… read more here.
Keywords: genome editing; non viral; crispr cas9; delivery ... See more keywords
Debugging the genetic code: non-viral in vivo delivery of therapeutic genome editing technologies.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in biomedical engineering"
DOI: 10.1016/j.cobme.2018.08.002
Abstract: Efforts to precisely correct genomic mutations that underlie hereditary diseases for therapeutic benefit have advanced alongside the emergence and improvement of genome engineering technologies. These methods can be divided into two main classes: active nucleasebased… read more here.
Keywords: genome editing; non viral; delivery; vivo delivery ... See more keywords
Oral Non-Viral Gene Delivery for Applications in DNA Vaccination and Gene Therapy.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in biomedical engineering"
DOI: 10.1016/j.cobme.2018.09.003
Abstract: Non-viral gene delivery via the oral route is a promising strategy for improving outcomes of DNA vaccination and gene therapy applications. Unlike traditional parenteral administration routes, the oral route is a non-invasive approach that lends… read more here.
Keywords: non viral; viral gene; gene delivery; gene ... See more keywords
Genetic therapies for cystic fibrosis lung disease
Sign Up to like & getrecommendations! Published in 2017 at "Current Opinion in Pharmacology"
DOI: 10.1016/j.coph.2017.10.006
Abstract: HighlightsGene editing strategies for gene therapy of cystic fibrosis.Chemically modified mRNA for CFTR protein replacement therapy.Better viral and non‐viral vectors targeted to lung epithelium.Human and animal models for CF. &NA; Gene therapy for cystic fibrosis… read more here.
Keywords: non viral; cystic fibrosis; fibrosis; gene therapy ... See more keywords
Glutathione targeted tragacanthic acid-chitosan as a non-viral vector for brain delivery of miRNA-219a-5P: An in vitro/in vivo study.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2022.01.100
Abstract: Multiple sclerosis (MS) is a progressive chronic demyelinating and neurodegenerative disease. The symptoms could only be diminished through stimulated remyelination. Although administration of microRNA-219a-5P (miR-219) seems to recover the damages, it is hampered by the… read more here.
Keywords: delivery; microscopy; non viral; mir 219 ... See more keywords