Cost-effectiveness Analysis of Bariatric Surgery for Patients With Nonalcoholic Steatohepatitis Cirrhosis
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DOI: 10.1001/jamanetworkopen.2019.0047
Abstract: Key Points Question Is bariatric surgery cost-effective in patients with nonalcoholic steatohepatitis and compensated cirrhosis? Findings In this simulation model study, laparoscopic sleeve gastrectomy had an incremental cost-effectiveness ratio of $66 119 per quality-adjusted life-year in… read more here.
Keywords: nonalcoholic steatohepatitis; cirrhosis; bariatric surgery; patients nonalcoholic ... See more keywords
Structure of proof of concept studies that precede a nonalcoholic steatohepatitis development program
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DOI: 10.1002/cpt.560
Abstract: Surrogate endpoints for clinical proof of concept (POC) trials in nonalcoholic steatohepatitis (NASH) are based upon expert pathological review of liver biopsies. During early development, these long‐term POC studies (≥48 weeks) add cost and time… read more here.
Keywords: proof concept; poc; development; nonalcoholic steatohepatitis ... See more keywords
The Role of Innate Immune Cells in Nonalcoholic Steatohepatitis
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DOI: 10.1002/hep.30506
Abstract: Inflammation and metabolic dysfunction are hallmarks of nonalcoholic steatohepatitis (NASH), which is one of the fastest‐growing liver diseases worldwide. Emerging evidence indicates that innate immune mechanisms are pivotal drivers of inflammation and other pathological manifestations… read more here.
Keywords: nonalcoholic steatohepatitis; cells nonalcoholic; role innate; immune cells ... See more keywords
Sestrin 3 Protects Against Diet‐Induced Nonalcoholic Steatohepatitis in Mice Through Suppression of Transforming Growth Factor β Signal Transduction
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DOI: 10.1002/hep.30820
Abstract: Sestrin 3 (Sesn3) belongs to the three‐member sestrin protein family. Sestrins have been implicated in antioxidative stress, adenosine monophosphate–activated protein kinase and mammalian target of rapamycin signal transduction, and metabolic homeostasis. However, the role of… read more here.
Keywords: nonalcoholic steatohepatitis; sesn3; diet induced; mice ... See more keywords
Nonalcoholic Steatohepatitis Is Associated With Liver‐Related Outcomes and All‐Cause Mortality in Chronic Hepatitis B
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DOI: 10.1002/hep.30857
Abstract: Chronic hepatitis B (CHB) and nonalcoholic fatty liver disease are increasingly observed together in clinical practice, and development of nonalcoholic steatohepatitis (NASH) represents another leading cause of liver‐related morbidity and mortality. Our aims were to… read more here.
Keywords: nonalcoholic steatohepatitis; mortality; liver related; chronic hepatitis ... See more keywords
Letter to the Editor: Chronic Hepatitis B and Nonalcoholic Steatohepatitis: Is “Fat” All Bad?
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DOI: 10.1002/hep.30983
Abstract: We read with interest the recent paper by Choi et al.(1) on the impact of biopsy-proven nonalcoholic steatohepatitis (NASH) on chronic hepatitis B (CHB) outcomes. The study concluded that compared to patients with CHB alone,… read more here.
Keywords: chronic hepatitis; chb; advanced fibrosis; nonalcoholic steatohepatitis ... See more keywords
Letter to the Editor: Hepatocellular Carcinoma Risk in Patients With Nonalcoholic Steatohepatitis Cirrhosis and Diabetes: Insufficient for Individual Management
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DOI: 10.1002/hep.31100
Abstract: We read with interest the article by Ju Dong Yang et al.(1) The study demonstrated that diabetes is associated with an increased risk of hepatocellular carcinoma (HCC) in patients with nonalcoholic steatohepatitis (NASH) cirrhosis and… read more here.
Keywords: hepatocellular carcinoma; risk; patients nonalcoholic; nonalcoholic steatohepatitis ... See more keywords
Therapeutic Potential of G Protein‐Coupled Receptors Against Nonalcoholic Steatohepatitis
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DOI: 10.1002/hep.31852
Abstract: Nonalcoholic steatohepatitis (NASH), the advanced stage of nonalcoholic fatty liver disease (NAFLD), affects approximately 6% of the population worldwide and is strongly associated with cardiometabolic disorders, placing subjects at a sharply increased risk of end-stage… read more here.
Keywords: protein coupled; therapeutic potential; coupled receptors; nonalcoholic steatohepatitis ... See more keywords
The Glucagon‐Like Peptide‐1 Receptor Agonist, Semaglutide, for the Treatment of Nonalcoholic Steatohepatitis
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DOI: 10.1002/hep.31886
Abstract: "A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis (1)," recently published in the New England Journal of Medicine (online November 2020) by Newsome et al., is an important investigation of the impact of 72… read more here.
Keywords: glucagon like; nonalcoholic steatohepatitis; treatment; receptor ... See more keywords
Breviscapine Alleviates Nonalcoholic Steatohepatitis by Inhibiting TGF-β-activated Kinase 1-dependent Signaling.
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DOI: 10.1002/hep.32221
Abstract: BACKGROUND & AIMS Nonalcoholic fatty liver disease (NAFLD) is a key component of metabolic syndrome ranging from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH) and is now becoming the leading cause of cirrhosis and… read more here.
Keywords: metabolic stress; breviscapine; signaling breviscapine; nonalcoholic steatohepatitis ... See more keywords
TRIM31 confers protection against nonalcoholic steatohepatitis by deactivating MAP3K7.
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DOI: 10.1002/hep.32526
Abstract: BACKGROUND AND AIMS As a global health threat, nonalcoholic steatohepatitis (NASH) has been confirmed to be a chronic progressive liver disease that is strongly associated with obesity. However, no approved drugs or efficient therapeutic strategies… read more here.
Keywords: nonalcoholic steatohepatitis; trim31 confers; protection nonalcoholic; confers protection ... See more keywords