Remodeling of the Conformational Dynamics of Noncanonical DNA Structures by Monomeric and Aggregated α-Synuclein.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.0c07192
Abstract: Research on Parkinson's disease most often focuses on the ability of the protein α-synuclein (α-syn) to form oligomers and amyloid fibrils, and how such species promote brain death. However, there are indications that α-syn also… read more here.
Keywords: monomeric aggregated; conformational dynamics; remodeling conformational; noncanonical dna ... See more keywords
Machine Learning Aids Classification and Discrimination of Noncanonical DNA Folding Motifs by an Arrayed Host:Guest Sensing System.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c06031
Abstract: An arrayed host:guest fluorescence sensor system can discriminate among and classify multiple different noncanonical DNA structures by exploiting selective molecular recognition. The sensor is highly selective and can discriminate between folds as similar as native… read more here.
Keywords: machine learning; dna; noncanonical dna; host guest ... See more keywords
Dynamics of physiologically relevant noncanonical DNA structures: an overview from experimental and theoretical studies.
Sign Up to like & getrecommendations! Published in 2018 at "Briefings in functional genomics"
DOI: 10.1093/bfgp/ely026
Abstract: DNA is a complex molecule with phenomenal inherent plasticity and the ability to form different hydrogen bonding patterns of varying stabilities. These properties enable DNA to attain a variety of structural and conformational polymorphic forms.… read more here.
Keywords: dna; dynamics physiologically; noncanonical dna; dna structures ... See more keywords