Indoleamine 2,3-Dioxygenase Activation by Interferon Gamma in Vascular Endothelial Cells Requires Noncanonical NF-κB Signaling.
Sign Up to like & getrecommendations! Published in 2019 at "Transplantation proceedings"
DOI: 10.1016/j.transproceed.2019.03.043
Abstract: Indoleamine 2,3-dioxygenase (IDO) is an important enzyme in immune response regulation; cells that express IDO can suppress T-cell responses. Endothelial cells (ECs) play an important role in graft rejection. Therefore, we investigated the role of… read more here.
Keywords: noncanonical signaling; endothelial cells; activation; interferon gamma ... See more keywords
4-1BB costimulation promotes CAR T cell survival through noncanonical NF-κB signaling
Sign Up to like & getrecommendations! Published in 2020 at "Science Signaling"
DOI: 10.1126/scisignal.aay8248
Abstract: Noncanonical NF-κB signaling enhances the survival of CAR T cells expressing the 4-1BB costimulatory domain. Ensuring the persistence of CAR T cells Optimal antitumor responses in patients treated with chimeric antigen receptor (CAR) T cells… read more here.
Keywords: car cell; persistence; noncanonical signaling; car cells ... See more keywords
IKKα-Mediated Noncanonical NF-κB Signaling Is Required To Support Murine Gammaherpesvirus 68 Latency In Vivo
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.00027-22
Abstract: The latency programs of the human gammaherpesviruses Epstein-Barr virus (EBV) and Kaposi sarcoma-associated herpesvirus (KSHV) are associated with B cell lymphomas. It is critical to understand the signaling pathways that are used by gammaherpesviruses to… read more here.
Keywords: noncanonical signaling; latency; murine gammaherpesvirus; virus ... See more keywords
Abstract B018: Loss of androgen receptor-mediated repression leads to EphA2 overexpression that promotes cellular dedifferentiation and castration resistance of prostate cancer through noncanonical signaling
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.prca2023-b018
Abstract: As a member of Eph subfamily receptor tyrosine kinases, EphA2 has been extensively studied in cancer. It is frequently overexpressed in many different types of human cancer, which is often correlated with tumor progression. We… read more here.
Keywords: prostate cancer; castration resistance; noncanonical signaling; receptor ... See more keywords