Predicting Total Drug Clearance and Volumes of Distribution Using the Machine Learning-Mediated Multimodal Method through the Imputation of Various Nonclinical Data
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Chemical Information and Modeling"
DOI: 10.1021/acs.jcim.2c00318
Abstract: Pharmacokinetic research plays an important role in the development of new drugs. Accurate predictions of human pharmacokinetic parameters are essential for the success of clinical trials. Clearance (CL) and volume of distribution (Vd) are important… read more here.
Keywords: clearance; nonclinical data; predicting total; imputation ... See more keywords
Specific pathologist responses for Standard for Exchange of Nonclinical Data (SEND)
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DOI: 10.1293/tox.2017-0019
Abstract: The Standard for Exchange of Nonclinical Data (SEND), introduced by the US Food and Drug Administration (FDA), is a scheme for the computerization, electronic application, and screening of preclinical data. Since its establishment, related organizations… read more here.
Keywords: standard exchange; pathology; exchange nonclinical; data send ... See more keywords