Using INFERNO to Infer the Molecular Mechanisms Underlying Noncoding Genetic Associations.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1158-6_6
Abstract: The INFERNO method provides an integrative computational framework for characterizing the causal variants, tissue contexts, affected regulatory mechanisms, and target genes underlying noncoding genetic variants associated with any phenotype or disease of interest. Here we… read more here.
Keywords: using inferno; infer molecular; underlying noncoding; molecular mechanisms ... See more keywords
Multiplexed functional genomic assays to decipher the noncoding genome.
Sign Up to like & getrecommendations! Published in 2022 at "Human molecular genetics"
DOI: 10.1093/hmg/ddac194
Abstract: Linkage disequilibrium and the incomplete regulatory annotation of the noncoding genome complicates the identification of functional noncoding genetic variants and their causal association with disease. Current computational methods for variant prioritization have limited predictive value,… read more here.
Keywords: noncoding genetic; genomic assays; multiplexed functional; assays decipher ... See more keywords