The noncoding genome and hearing loss.
Sign Up to like & getrecommendations! Published in 2021 at "Human genetics"
DOI: 10.1007/s00439-021-02359-z
Abstract: The age of sequencing has provided unprecedented insights into the human genome. The coding region of the genome comprises nearly 20,000 genes, of which approximately 4000 are associated with human disease. Beyond the protein-coding genome,… read more here.
Keywords: hearing loss; genome hearing; noncoding genome;
Multiplexed functional genomic assays to decipher the noncoding genome.
Sign Up to like & getrecommendations! Published in 2022 at "Human molecular genetics"
DOI: 10.1093/hmg/ddac194
Abstract: Linkage disequilibrium and the incomplete regulatory annotation of the noncoding genome complicates the identification of functional noncoding genetic variants and their causal association with disease. Current computational methods for variant prioritization have limited predictive value,… read more here.
Keywords: noncoding genetic; genomic assays; multiplexed functional; assays decipher ... See more keywords
Ontogeny and heterogeneity of innate lymphoid cells and the noncoding genome
Sign Up to like & getrecommendations! Published in 2021 at "Immunological Reviews"
DOI: 10.1111/imr.12950
Abstract: Since their discovery a decade ago, it has become evident that innate lymphoid cells (ILCs) play critical roles in protective immune responses against intracellular and extracellular pathogens but are also central regulators of epithelial barrier… read more here.
Keywords: heterogeneity; innate lymphoid; lymphoid cells; development ... See more keywords