Differential Allele-Specific Expression Uncovers Breast Cancer Genes Dysregulated by Cis Noncoding Mutations.
Sign Up to like & getrecommendations! Published in 2020 at "Cell systems"
DOI: 10.1016/j.cels.2020.01.002
Abstract: Identifying cancer-relevant mutations in noncoding regions is challenging due to the large numbers of such mutations, their low levels of recurrence, and difficulties in interpreting their functional impact. To uncover genes that are dysregulated due… read more here.
Keywords: noncoding mutations; ase; allele specific; cancer ... See more keywords
A global transcriptional network connecting noncoding mutations to changes in tumor gene expression
Sign Up to like & getrecommendations! Published in 2018 at "Nature genetics"
DOI: 10.1038/s41588-018-0091-2
Abstract: Although cancer genomes are replete with noncoding mutations, the effects of these mutations remain poorly characterized. Here we perform an integrative analysis of 930 tumor whole genomes and matched transcriptomes, identifying a network of 193… read more here.
Keywords: network; noncoding mutations; gene expression; expression ... See more keywords
Diverse noncoding mutations contribute to deregulation of cis-regulatory landscape in pediatric cancers
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.aba3064
Abstract: Joint analysis of genomic and transcriptomic data reveals diverse noncoding mutation landscapes in five types of pediatric cancers. Interpreting the function of noncoding mutations in cancer genomes remains a major challenge. Here, we developed a… read more here.
Keywords: deregulation cis; contribute deregulation; noncoding mutations; diverse noncoding ... See more keywords
Abstract 2280: Systematic analysis of causal noncoding mutations in pediatric B-cell acute lymphoblastic leukemia
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-2280
Abstract: B cell acute lymphoblastic leukemia (B-ALL) is the most prevalent childhood hematological malignancy and the leading cause of childhood cancer-related mortality. To date, the molecular pathogenesis of B-ALL has not been completely defined, limiting our… read more here.
Keywords: cell acute; noncoding mutations; analysis; causal ... See more keywords
Novel oncogenic noncoding mutations in T-ALL.
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DOI: 10.1182/blood-2017-04-773242
Abstract: In this issue of Blood , Rahman et al 1 and Hu et al 2 identify somatic alterations targeting noncoding elements in the vicinity of LMO1 and LMO2 as novel mechanisms of oncogene activation in… read more here.
Keywords: noncoding mutations; novel oncogenic; oncogenic noncoding;
Role of ZNF143 and Its Association with Gene Expression Patterns, Noncoding Mutations, and the Immune System in Human Breast Cancer
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DOI: 10.3390/life13010027
Abstract: The function of noncoding sequence variations at ZNF143 binding sites in breast cancer cells is currently not well understood. Distal elements and promoters, also known as cis-regulatory elements, control the expression of genes. They may… read more here.
Keywords: expression; breast cancer; gene expression; noncoding mutations ... See more keywords