Structure Validation of G‐Rich RNAs in Noncoding Regions of the Human Genome
Sign Up to like & getrecommendations! Published in 2020 at "Chembiochem"
DOI: 10.1002/cbic.201900696
Abstract: We present the rapid biophysical characterization of six previously reported putative G‐quadruplex‐forming RNAs from the 5′‐untranslated region (5′‐UTR) of silvestrol‐sensitive transcripts for investigation of their secondary structures. By NMR and CD spectroscopic analysis, we found… read more here.
Keywords: rnas noncoding; rich rnas; structure validation; validation rich ... See more keywords
Prediction of disease‐associated functional variants in noncoding regions through a comprehensive analysis by integrating datasets and features
Sign Up to like & getrecommendations! Published in 2021 at "Human Mutation"
DOI: 10.1002/humu.24203
Abstract: One of the greatest challenges in human genetics is deciphering the link between functional variants in noncoding sequences and the pathophysiology of complex diseases. To address this issue, many methods have been developed to sort… read more here.
Keywords: variants noncoding; prediction disease; functional variants; disease associated ... See more keywords
Candidate Regulatory Elements in Coding and Noncoding Regions are Associated With Invasive Behavior in Pituitary Tumors
Sign Up to like & getrecommendations! Published in 2019 at "Neurosurgery"
DOI: 10.1093/neuros/nyz310_157
Abstract: Unique genome-wide DNA methylation patterns have been shown to define pituitary tumors (PT) by functional subtypes and play a relevant role in the pathogenesis of these tumors. Indeed, it is known that several tumor suppressor… read more here.
Keywords: invasive behavior; noncoding regions; associated invasive; behavior pituitary ... See more keywords
Synergistic Effect between 3′-Terminal Noncoding and Adjacent Coding Regions of the Influenza A Virus Hemagglutinin Segment on Template Preference
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DOI: 10.1128/jvi.00878-21
Abstract: While most influenza A virus vRNA segments contain segment-specific nonconserved noncoding regions of similar length and sequence, these regions vary considerably both in length and sequence in the segments encoding HA and NA, the two… read more here.
Keywords: template preference; adjacent coding; noncoding regions; sequence ... See more keywords
Evolution of the Noncoding Features of Sea Snake Mitochondrial Genomes within Elapidae
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DOI: 10.3390/genes13081470
Abstract: Mitochondrial genomes of four elapid snakes (three marine species [Emydocephalus ijimae, Hydrophis ornatus, and Hydrophis melanocephalus], and one terrestrial species [Sinomicrurus japonicus]) were completely sequenced by a combination of Sanger sequencing, next-generation sequencing and Nanopore… read more here.
Keywords: noncoding regions; sea snake; mitochondrial genomes; sea snakes ... See more keywords