In silico identification of noncompetitive inhibitors targeting an uncharacterized allosteric site of falcipain-2
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DOI: 10.1007/s10822-021-00420-7
Abstract: Falcipain-2 (FP-2) is a Plasmodium falciparum hemoglobinase widely targeted in the search for antimalarials. FP-2 can be allosterically modulated by various noncompetitive inhibitors that have been serendipitously identified. Moreover, the crystal structures of two inhibitors… read more here.
Keywords: noncompetitive inhibitors; silico identification; site; falcipain ... See more keywords