Selective noncovalent proteasome inhibiting activity of trifluoromethyl-containing gem-quaternary aziridines.
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DOI: 10.1002/ardp.202300174
Abstract: The ubiquitin-proteasome pathway (UPP) represents the principal proteolytic apparatus in the cytosol and nucleus of all eukaryotic cells. Nowadays, proteasome inhibitors (PIs) are well-known as anticancer agents. However, although three of them have been approved… read more here.
Keywords: trifluoromethyl; aziridines selective; proteasome inhibiting; noncovalent proteasome ... See more keywords