THU0301 Safety following initiation of rituximab in granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA): interim analysis of the rituximab in anca-associated vasculitis registry (RAVER)
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DOI: 10.1136/annrheumdis-2017-eular.1177
Abstract: Background Therapy-related serious adverse events (SAEs) are important causes of morbidity in patients with GPA or MPA. Long-term safety data of rituximab in GPA/MPA are limited. Objectives To characterize safety events in an observational registry… read more here.
Keywords: rituximab; none declared; gpa mpa; safety ... See more keywords
FRI0702 2-year outcome of 1077 patients with recent-onset inflammatory arthritis
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DOI: 10.1136/annrheumdis-2017-eular.1354
Abstract: Background Recent-onset inflammatory arthritis (IA) may represent a broad range of diseases. Few studies have examined the full spectrum of diagnostic outcomes in an unselected cohort of recent-onset IA patients. Objectives To describe the disease… read more here.
Keywords: none declared; year; recent onset; arthritis ... See more keywords
FRI0369 Prospective evaluation of the capillaroscopic skin ulcer index (CSURI) in clinical practice
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DOI: 10.1136/annrheumdis-2017-eular.1827
Abstract: Background Nailfold videocapillaroscopy (NVC) is an imaging technique representing a reliable tool for the classification, diagnosis and monitoring of systemic sclerosis (SSc) patients. The capillaroscopic skin ulcer index (CSURI) was suggested to identify patients at… read more here.
Keywords: capillaroscopic skin; none declared; index; skin ulcer ... See more keywords
OP0330 FRA2 overexpression leads to systemic autoimmunity by decreasing IL-2 responsiveness and thymic treg development
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DOI: 10.1136/annrheumdis-2017-eular.1850
Abstract: Background Fos-related antigen 2 (Fra2) is a transcription factor belonging to the Fos family proteins which is part of the AP-1 transcription complex. We recently described a Fra2 transgenic (tg) mouse model which develops a… read more here.
Keywords: none declared; cell; fra2 mice; mice ... See more keywords
OP0197 Evaluation of a dosing regimen for tocilizumab in patients younger than two years of age with systemic juvenile idiopathic arthritis
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DOI: 10.1136/annrheumdis-2017-eular.2386
Abstract: Background Tocilizumab (TCZ) is approved for the treatment of systemic juvenile idiopathic arthritis (sJIA) based on clinical trials in patients (pts) ≥2 years of age. This study (NP25737) is the first for a biologic in… read more here.
Keywords: none declared; age; years age; sjia ... See more keywords
FRI0445 Faecal calprotectin, but not anti-saccharomyces cerevisiae antibodies, is linked to worse disease status in axial spondyloarthritis patients without inflammatory bowel disease: results from the spartakus cohort
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DOI: 10.1136/annrheumdis-2017-eular.2391
Abstract: Background Inflammatory bowel disease (IBD) is a common comorbidity in axial spondyloarthritis. Objectives To study faecal calprotectin (F-calprotectin) levels and anti-Saccharomyces cerevisiae antibodies (ASCA) and their associations with disease status and gastrointestinal (GI) symptoms in… read more here.
Keywords: none declared; disease; calprotectin; axial spondyloarthritis ... See more keywords
OP0126 A phase 2 study of safety and efficacy of anabasum (JBT-101) in systemic sclerosis
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DOI: 10.1136/annrheumdis-2017-eular.2712
Abstract: Background Anabasum (JBT-101) is a synthetic, oral, non-immunosuppressive, preferential CB2 agonist. It inhibits onset and activates resolution of innate immune responses in animal models of systemic sclerosis (SSc). Objectives Evaluate safety and efficacy of anabasum… read more here.
Keywords: anabasum subjects; none declared; safety; acr criss ... See more keywords
SAT0366 Smoking behaviour and the progression of organ manifestations in systemic sclerosis: a longitudinal european scleroderma trials and research group study
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DOI: 10.1136/annrheumdis-2017-eular.2729
Abstract: Background Systemic sclerosis (SSc) is a rare, multisystem autoimmune disorder. It is characterised by generalized microangiopathy, in which hypoxia and oxidative stress have been implicated in its pathogenesis. Tobacco inhalation increases free radicals and strongly… read more here.
Keywords: organ manifestations; current smokers; none declared; ssc ... See more keywords
AB0444 Effect of rituximab on a salivary gland ultrasound score in primary sjÖgren's syndrome: results of the tractiss multicentre randomised trial sub-study
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DOI: 10.1136/annrheumdis-2017-eular.3138
Abstract: Background B lymphocytes are important in the pathogenesis of primary Sjögren's syndrome (PSS), but two phase III trials (TEARS and TRACTISS) of the B cell depleting agent rituximab (RTX) failed to show an effect on… read more here.
Keywords: none declared; week; rtx; baseline ... See more keywords
AB0357 Sexuality in women with rheumatoid arthritis - results of a survey
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DOI: 10.1136/annrheumdis-2017-eular.3437
Abstract: Background Diseases such as rheumatoid arthritis (RA) are distinguished by their chronic and progressive characteristics; they may lead to premature loss of joint function and constitute major social, economic and health burdens. Rheumatic diseases may… read more here.
Keywords: none; disease activity; none declared; sexual dysfunction ... See more keywords
THU0507 Long-term experience with adalimumab for the treatment of juvenile idiopathic arthritis. 5- year data from the german biker registry
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DOI: 10.1136/annrheumdis-2017-eular.3457
Abstract: Background Since the approval of Adalimumab (ADA) for treatment of juvenile idiopathic arthritis (JIA), it has become a valuable option, which significantly improved the outcome of patients. Objectives To report efficacy (as observed) and safety… read more here.
Keywords: combination; none declared; jia; german biker ... See more keywords