4-Hydroxy-2-nonenal causes nuclear accumulation of p62 by inhibiting Xpo1 and promoting the proteolytic pathway in the nucleus
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DOI: 10.1371/journal.pone.0316558
Abstract: p62, an adapter protein involved in selective autophagy, is mainly found in the cytoplasm under normal conditions. Because p62 has nuclear localization signal (NLS) and a nuclear export signal, it has been suggested that p62… read more here.
Keywords: nuclear accumulation; p62; nonenal causes; inhibiting xpo1 ... See more keywords