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   Articles with "nonheme iron" as a keyword



Artificial nonheme iron and manganese oxygenases for enantioselective olefin epoxidation and alkane hydroxylation reactions

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recommendations! Published in 2020 at "Coordination Chemistry Reviews"

DOI: 10.1016/j.ccr.2020.213443

Abstract: Abstract The development of sustainable enantioselective olefin epoxidation and alkane oxidation reactions under environmentally friendly conditions is an ultimate goal that has long been pursued in chemistry. Excellent examples are naturally occurring monooxygenases, which are… read more here.

Keywords: oxidation; chemistry; epoxidation; nonheme iron ... See more keywords

Use of Singlet Oxygen in the Generation of a Mononuclear Nonheme Iron(IV)-Oxo Complex.

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recommendations! Published in 2023 at "Inorganic chemistry"

DOI: 10.1021/acs.inorgchem.2c04020

Abstract: Nonheme iron(III)-superoxo intermediates are generated in the activation of dioxygen (O2) by nonheme iron(II) complexes and then converted to iron(IV)-oxo species by reacting with hydrogen donor substrates with relatively weak C-H bonds. If singlet oxygen… read more here.

Keywords: iron oxo; iron; chemistry; nonheme iron ... See more keywords

Enhanced Reactivity through Equatorial Sulfur Coordination in Nonheme Iron(IV)-Oxo Complexes: Insights from Experiment and Theory.

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recommendations! Published in 2024 at "Inorganic chemistry"

DOI: 10.1021/acs.inorgchem.4c00070

Abstract: Sulfur ligation in metalloenzymes often gives the active site unique properties, whether it is the axial cysteinate ligand in the cytochrome P450s or the equatorial sulfur/thiol ligation in nonheme iron enzymes. To understand sulfur ligation… read more here.

Keywords: oxo complexes; iron; iron oxo; nonheme iron ... See more keywords

Theoretical Study of the Mechanism of the Nonheme Iron Enzyme EgtB.

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recommendations! Published in 2017 at "Inorganic chemistry"

DOI: 10.1021/acs.inorgchem.6b03177

Abstract: EgtB is a nonheme iron enzyme catalyzing the C-S bond formation between γ-glutamyl cysteine (γGC) and N-α-trimethyl histidine (TMH) in the ergothioneine biosynthesis. Density functional calculations were performed to elucidate and delineate the reaction mechanism… read more here.

Keywords: mechanism; iron enzyme; bond; iron ... See more keywords

Computational Electrochemistry as a Reliable Probe of Experimentally Elusive Mononuclear Nonheme Iron Species

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recommendations! Published in 2018 at "Journal of Physical Chemistry C"

DOI: 10.1021/acs.jpcc.8b02698

Abstract: Despite the growing number of reported FeIVO complexes, an unambiguous experimental characterization of their redox properties, such as one-electron reduction potentials, remains a challenging task. To this aim, we describe an efficient and straightforward theoretical… read more here.

Keywords: mononuclear nonheme; methodology; electrochemistry; nonheme iron ... See more keywords

Probing Ferryl Reactivity in a Nonheme Iron Oxygenase Using an Expanded Genetic Code

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recommendations! Published in 2024 at "ACS Catalysis"

DOI: 10.1021/acscatal.4c02365

Abstract: The ability to introduce noncanonical amino acids as axial ligands in heme enzymes has provided a powerful experimental tool for studying the structure and reactivity of their FeIV=O (“ferryl”) intermediates. Here, we show that a… read more here.

Keywords: ferryl reactivity; reactivity nonheme; probing ferryl; nonheme iron ... See more keywords

What Drives Radical Halogenation versus Hydroxylation in Mononuclear Nonheme Iron Complexes? A Combined Experimental and Computational Study

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recommendations! Published in 2022 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.2c01375

Abstract: Nonheme iron halogenases are unique enzymes in nature that selectively activate an aliphatic C–H bond of a substrate to convert it into C–X (X = Cl/Br, but not F/I). It is proposed that they generate… read more here.

Keywords: secondary carbon; transfer; iron; halogenation ... See more keywords

Nonheme Iron(III) Azide and Iron(III) Isothiocyanate Complexes: Radical Rebound Reactivity, Selectivity, and Catalysis.

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recommendations! Published in 2022 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.2c07224

Abstract: The new nonheme iron complexes FeII(BNPAPh2O)(N3) (1), FeIII(BNPAPh2O)(OH)(N3) (2), FeII(BNPAPh2O)(OH) (3), FeIII(BNPAPh2O)(OH)(NCS) (4), FeII(BNPAPh2O)(NCS) (5), FeIII(BNPAPh2O)(NCS)2 (6), and FeIII(BNPAPh2O)(N3)2 (7) (BNPAPh2O = 2-(bis((6-(neopentylamino)pyridin-2-yl) methyl)amino)-1,1-diphenylethanolate) were synthesized and characterized by single crystal X-ray diffraction (XRD), as… read more here.

Keywords: iron; nonheme iron; iron iii; bnpaph2o ... See more keywords

A Nonheme Iron(III) Superoxide Complex Leads to Sulfur Oxygenation.

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recommendations! Published in 2024 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.3c12337

Abstract: A new alkylthiolate-ligated nonheme iron complex, FeII(BNPAMe2S)Br (1), is reported. Reaction of 1 with O2 at -40 °C, or reaction of the ferric form with O2•- at -80 °C, gives a rare iron(III)-superoxide intermediate, [FeIII(O2)(BNPAMe2S)]+… read more here.

Keywords: iron iii; iron; superoxide complex; complex leads ... See more keywords

Biocatalytic Synthesis of N-Protected α-Amino Acids through 1,3-Nitrogen Migration by Nonheme Iron Enzymes.

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recommendations! Published in 2025 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.5c11008

Abstract: Nonheme iron enzymes rank among nature's most versatile catalysts for molecular functionalization. Their flexible coordination environments provide a unique platform for expanding the scope of new-to-nature metalloenzymatic catalysis. Leveraging this feature, we herein present a… read more here.

Keywords: iron enzymes; amino acids; nonheme iron; nitrogen migration ... See more keywords

Mutable Properties of Nonheme Iron(III)-Iodosylarene Complexes Result in the Elusive Multiple-Oxidant Mechanism.

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recommendations! Published in 2017 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.7b03310

Abstract: Although nonheme iron(III)-iodosylarene complexes present amazing oxidative efficiency and selectivity, the nature of such complexes and related oxidation mechanism are still unsolved after decades of experimental efforts. Density functional calculations were employed to explore the… read more here.

Keywords: mechanism; iii iodosylarene; iron; iron iii ... See more keywords