Synthesis of 6,6‐ and 7,7‐Difluoro‐1‐acetamidopyrrolizidines and Their Oxidation Catalyzed by the Nonheme Fe Oxygenase LolO
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DOI: 10.1002/cbic.202200081
Abstract: LolO, a 2‐oxoglutarate‐dependent nonheme Fe oxygenase, catalyzes both the hydroxylation of 1‐exo‐acetamidopyrrolizidine (AcAP), a pathway intermediate in the biosynthesis of the loline alkaloids, and the cycloetherification of the resulting alcohol. We have prepared fluorinated AcAP… read more here.
Keywords: difluoro; nonheme oxygenase; acap; synthesis difluoro ... See more keywords