Quantitative Analysis of Nonhistone Lysine Methylation Sites and Lysine Demethylases in Breast Cancer Cell Lines.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.4c00685
Abstract: Growing evidence shows that lysine methylation is a widespread protein post-translational modification (PTM) that regulates protein function on histone and nonhistone proteins. Numerous studies have demonstrated that the dysregulation of lysine methylation mediators contributes to… read more here.
Keywords: cancer; methylation; nonhistone; cell lines ... See more keywords
nhKcr: a new bioinformatics tool for predicting crotonylation sites on human nonhistone proteins based on deep learning.
Sign Up to like & getrecommendations! Published in 2021 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbab146
Abstract: Lysine crotonylation (Kcr) is a newly discovered type of protein post-translational modification and has been reported to be involved in various pathophysiological processes. High-resolution mass spectrometry is the primary approach for identification of Kcr sites.… read more here.
Keywords: nonhistone proteins; nonhistone; kcr sites; predicting crotonylation ... See more keywords
Nonhistone lactylation: A hub for tumour metabolic reprogramming and epigenetic regulation
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-025-06813-8
Abstract: Recent research has shifted the perception of lactate from being merely a byproduct of metabolism to being a crucial signalling molecule and epigenetic regulator in tumours. This paper provides a comprehensive review of the mechanisms… read more here.
Keywords: nonhistone lactylation; nonhistone; lactylation; lactylation hub ... See more keywords