Design and Interpretation of Noninferiority Trials
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DOI: 10.1007/s11606-018-4505-8
Abstract: A uthors’ reply: We are grateful for the correspondents’ interest in our descriptive study of noninferiority trials.1 Turgeon et al. have retrospectively extended the part of our analysis comparing ITT (intention-to-treat) and PP (perprotocol) methodologies… read more here.
Keywords: medicine; design interpretation; interpretation noninferiority; noninferiority ... See more keywords
Non-inferiority Trial Design in Drug Development: A Primer for Cardiovascular Healthcare Professionals
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DOI: 10.1007/s40256-019-00378-w
Abstract: Noninferiority trials, in which a new treatment is compared with a standard active treatment, are becoming increasingly popular in cardiovascular medicine. A noninferiority trial seeks to test whether the effect of a new drug is… read more here.
Keywords: medicine; trial; design; drug ... See more keywords
Most noninferiority trials were not designed to preserve active comparator treatment effects.
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DOI: 10.1016/j.jclinepi.2019.03.003
Abstract: OBJECTIVES To evaluate whether noninferiority trials are designed to adequately preserve the historical treatment effect of their active comparators. STUDY DESIGN AND SETTING We reviewed 162 noninferiority trials published in high-impact medical journals. We assessed… read more here.
Keywords: active comparator; treatment; trials designed; noninferiority trials ... See more keywords
THE REPORTING QUALITY OF NONINFERIORITY TRIALS USING INTRAVITREAL VASCULAR ENDOTHELIAL GROWTH FACTOR INHIBITORS
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DOI: 10.1097/iae.0000000000003649
Abstract: Supplemental Digital Content is Available in the Text. Noninferiority trials that explore antiintravitreal vascular endothelial growth factor inhibitor therapies for the management of ocular diseases generally attain noninferiority of the studied intervention. However, reporting limitations… read more here.
Keywords: endothelial growth; noninferiority; growth factor; noninferiority trials ... See more keywords