Phase 2 study for nonmetastatic extremity high-grade osteosarcoma in pediatric and adolescent and young adult patients with a risk-adapted strategy based on ABCB1/P-glycoprotein expression: An Italian Sarcoma Group trial (ISG/OS-2).
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DOI: 10.1002/cncr.34131
Abstract: BACKGROUND According to retrospective osteosarcoma series, ABCB1/P-glycoprotein (Pgp) overexpression predicts for poor outcomes. A prospective trial to assess a risk-adapted treatment strategy using mifamurtide in Pgp+ patients was performed. METHODS This was a phase 2,… read more here.
Keywords: abcb1 glycoprotein; osteosarcoma; trial; nonmetastatic extremity ... See more keywords