Nonmuscle myosin-2 isoforms
Sign Up to like & getrecommendations! Published in 2019 at "Current Biology"
DOI: 10.1016/j.cub.2019.03.022
Abstract: A hallmark of eukaryotes is the ability to generate microscale movements from the molecular to the tissue-length scales. Members of the myosin and actin protein families form the actomyosin cytoskeleton and are responsible for these… read more here.
Keywords: myosin isoforms; biology; nonmuscle myosin;
Nonmuscle myosin heavy chain IIA facilitates SARS-CoV-2 infection in human pulmonary cells
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2111011118
Abstract: Significance SARS-CoV-2 primarily targets the lung and enters the body through ACE2 receptors. However, the expression of ACE2 is extremely low in the airways. In this study, we utilized APEX2 proximity-labeling techniques and identified nonmuscle… read more here.
Keywords: myosin heavy; cov infection; sars cov; nonmuscle myosin ... See more keywords
Nonmuscle Myosin II Activation Regulates Cell Proliferation, Cell Contraction, and Myofibroblast Differentiation in Keloid-Derived Fibroblasts.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in wound care"
DOI: 10.1089/wound.2019.0944
Abstract: Objective: Keloid is an abnormal scar that often develops in high-tension skin. It is caused by excessive fibroblast proliferation and collagen deposition. Nonmuscle myosin IIA (NM-IIA) is an important motor protein that regulates the mechanical… read more here.
Keywords: proliferation cell; cell proliferation; proliferation; iia ... See more keywords
Unique and redundant functions of cytoplasmic actins and nonmuscle myosin II isoforms at epithelial junctions
Sign Up to like & getrecommendations! Published in 2022 at "Annals of the New York Academy of Sciences"
DOI: 10.1111/nyas.14808
Abstract: The integrity and functions of epithelial barriers depend on the formation of adherens junctions (AJs) and tight junctions (TJs). A characteristic feature of AJs and TJs is their association with the cortical cytoskeleton composed of… read more here.
Keywords: actin isoforms; redundant functions; myosin; unique redundant ... See more keywords
Common and Specific Functions of Nonmuscle Myosin II Paralogs in Cells
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry (Moscow)"
DOI: 10.1134/s0006297918120040
Abstract: Various forms of cell motility critically depend on pushing, pulling, and resistance forces generated by the actin cytoskeleton. Whereas pushing forces largely depend on actin polymerization, pulling forces responsible for cell contractility and resistance forces… read more here.
Keywords: specific functions; paralogs cells; functions nonmuscle; myosin paralogs ... See more keywords
Nonmuscle myosin IIA is involved in recruitment of apical junction components through activation of α-catenin
Sign Up to like & getrecommendations! Published in 2018 at "Biology Open"
DOI: 10.1242/bio.031369
Abstract: ABSTRACT MDCK dog kidney epithelial cells express two isoforms of nonmuscle myosin heavy chain II, IIA and IIB. Using the CRISPR/Cas9 system, we established cells in which the IIA gene was ablated. These cells were… read more here.
Keywords: iia cells; cell; gfp iia; nonmuscle myosin ... See more keywords
Nonmuscle myosin IIB regulates epicardial integrity and epicardium-derived mesenchymal cell maturation
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cell Science"
DOI: 10.1242/jcs.202564
Abstract: ABSTRACT Nonmuscle myosin IIB (NMIIB; heavy chain encoded by MYH10) is essential for cardiac myocyte cytokinesis. The role of NMIIB in other cardiac cells is not known. Here, we show that NMIIB is required in… read more here.
Keywords: cell; myosin iib; nonmuscle myosin; epicardial integrity ... See more keywords