Impact of Nonnative Interactions on the Binding Kinetics of Intrinsically Disordered p53 with MDM2: Insights from All-Atom Simulation and Markov State Model Analysis
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DOI: 10.1021/acs.jcim.3c01833
Abstract: Intrinsically disordered proteins (IDPs) lack a well-defined tertiary structure but are essential players in various biological processes. Their ability to undergo a disorder-to-order transition upon binding to their partners, known as the folding-upon-binding process, is… read more here.
Keywords: intrinsically disordered; simulation markov; nonnative interactions; p53 ... See more keywords