Deciphering the Molecular Characteristics of Human Idiopathic Nonobstructive Azoospermia from the Perspective of Germ Cells.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202206852
Abstract: Nonobstructive azoospermia (NOA) is one of the most important causes of male infertility, accounting for 10-15% of infertile men worldwide. Among these, more than 70% of cases are idiopathic NOA (iNOA), whose pathogenesis and molecular… read more here.
Keywords: perspective germ; cell; nonobstructive azoospermia; germ cells ... See more keywords
STX2 is a causative gene for nonobstructive azoospermia
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DOI: 10.1002/humu.23423
Abstract: STX2 encodes a sulfoglycolipid transporter. Although Stx2 nullizygosity is known to cause spermatogenic failure in mice, STX2 mutations have not been identified in humans. Here, we performed STX2 mutation analysis for 131 Japanese men clinically… read more here.
Keywords: nonobstructive azoospermia; stx2 causative; stx2; mutation ... See more keywords
Ultrasonographically determined size of seminiferous tubules predicts sperm retrieval by microdissection testicular sperm extraction in men with nonobstructive azoospermia.
Sign Up to like & getrecommendations! Published in 2020 at "Fertility and sterility"
DOI: 10.1016/j.fertnstert.2019.08.061
Abstract: OBJECTIVE To investigate the value of the ultrasonographically determined size of seminiferous tubules and other conventional parameters for predicting sperm retrieval by microdissection testicular sperm extraction (micro-TESE). DESIGN Clinical retrospective study. SETTING Two urological clinics.… read more here.
Keywords: ultrasonographically determined; men nonobstructive; seminiferous tubules; sperm retrieval ... See more keywords
Predictive model to estimate the chances of successful sperm retrieval by testicular sperm aspiration in patients with nonobstructive azoospermia.
Sign Up to like & getrecommendations! Published in 2020 at "Fertility and sterility"
DOI: 10.1016/j.fertnstert.2020.08.1397
Abstract: OBJECTIVE To explore predictors of successful sperm retrieval (SR) and to identify potentially suitable candidates for testicular sperm aspiration (TESA), a more straightforward, less traumatic, and less costly procedure than open surgical SR methods. DESIGN… read more here.
Keywords: testicular sperm; successful sperm; predictive model; model ... See more keywords
Feasibility of repeat microdissection testicular sperm extraction within 6 months for nonobstructive azoospermia
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the Chinese Medical Association"
DOI: 10.1097/jcma.0000000000000842
Abstract: Background: Microdissection testicular sperm extraction (mTESE) is the mainstay of sperm retrieval in men with nonobstructive azoospermia (NOA). Some experts believe that a resting period of ≥6 months is required between procedures to ensure better… read more here.
Keywords: nonobstructive azoospermia; within months; testicular sperm; microdissection testicular ... See more keywords
Parameters predicting sperm retrieval rates during microscopic testicular sperm extraction in nonobstructive azoospermia
Sign Up to like & getrecommendations! Published in 2019 at "Andrologia"
DOI: 10.1111/and.13441
Abstract: The aim of this study was to investigate the predictive value of the parameters that might have an effect on the success of microscopic testicular sperm extraction (micro‐TESE) in infertile patients with nonobstructive azoospermia (NOA).… read more here.
Keywords: testicular sperm; micro tese; microscopic testicular; sperm extraction ... See more keywords
Whole‐genome sequencing identifies new candidate genes for nonobstructive azoospermia
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DOI: 10.1111/andr.13269
Abstract: Genetic causes that lead to spermatogenetic failure in patients with nonobstructive azoospermia (NOA) have not been yet completely established. read more here.
Keywords: nonobstructive azoospermia; genome sequencing; identifies new; sequencing identifies ... See more keywords
A complete dissection of the whole testicular parenchyma is required in most patients with nonobstructive azoospermia to obtain enough good quality testicular spermatozoa for ICSI
Sign Up to like & getrecommendations! Published in 2022 at "Andrology"
DOI: 10.1111/andr.13344
Abstract: Due to the heterogeneous distribution of seminiferous tubules (STs) in patients with nonobstructive azoospermia (NOA), retrieving enough good quality spermatozoa for ICSI may require a complete testicular dissection. According to the only available study in… read more here.
Keywords: nonobstructive azoospermia; patients nonobstructive; spermatozoa icsi; dissection ... See more keywords
Interaction between Host and Microbes in the Semen of Patients with Idiopathic Nonobstructive Azoospermia
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DOI: 10.1128/spectrum.04365-22
Abstract: Idiopathic nonobstructive azoospermia is one of the great challenges in assisted reproductive therapy. Although microdissection testicular sperm extraction technology is currently available, many men with iNOA still face the problem of poor sperm retrieval and… read more here.
Keywords: poor sperm; nonobstructive azoospermia; sperm quality; idiopathic nonobstructive ... See more keywords
Altered microRNA profiles of testicular biopsies from patients with nonobstructive azoospermia
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DOI: 10.4103/aja.aja_35_19
Abstract: Many studies have shown that microRNAs (miRNAs) play vital roles during the spermatogenesis. However, little is known about the altered miRNA profiles of testicular tissues in nonobstructive azoospermia (NOA). Using microarray technology, the miRNA expression… read more here.
Keywords: profiles testicular; biopsies patients; testicular biopsies; expression ... See more keywords
MBOAT1 homozygous missense variant causes nonobstructive azoospermia.
Sign Up to like & getrecommendations! Published in 2021 at "Asian journal of andrology"
DOI: 10.4103/aja202160
Abstract: Nonobstructive azoospermia (NOA) is a common cause of infertility and is defined as the complete absence of sperm in ejaculation due to defective spermatogenesis. The aim of this study was to identify the genetic etiology… read more here.
Keywords: mboat1; variant; homozygous missense; missense variant ... See more keywords