Improved A40926 Production from Nonomuraea gerenzanensis Using the Promoter Engineering and the Co-expression of Crucial Genes.
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DOI: 10.1016/j.jbiotec.2020.09.017
Abstract: The semi-synthetic antibiotic dalbavancin is clinically used in the treatment of severe infections caused by multidrug resistant Gram-positive pathogens. So far, fermentation has still been the only approach for the production of A40926 in the… read more here.
Keywords: production; gerenzanensis; expression; nonomuraea gerenzanensis ... See more keywords
New Molecular Tools for Regulation and Improvement of A40926 Glycopeptide Antibiotic Production in Nonomuraea gerenzanensis ATCC 39727
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DOI: 10.3389/fmicb.2020.00008
Abstract: Genome sequencing has revealed that Nonomuraea spp. represent a still largely unexplored source of specialized metabolites. Nonomuraea gerenzanensis ATCC 39727 is the most studied representative species since it produces the glycopeptide antibiotic (GPA) A40926 –… read more here.
Keywords: production; gerenzanensis; gerenzanensis atcc; a40926 ... See more keywords