Pregnancy Increases Norbuprenorphine Clearance in Mice by Induction of Hepatic Glucuronidation
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DOI: 10.1124/dmd.117.076745
Abstract: Norbuprenorphine (NBUP) is the major active metabolite of buprenorphine (BUP) that is commonly used to treat opiate addiction during pregnancy; it possesses 25% of BUP’s analgesic activity and 10 times BUP’s respiratory depression effect. To… read more here.
Keywords: pregnancy; induction hepatic; liver; nonpregnant mice ... See more keywords