Characterization and Structural Determination of CmnG‐A, the Adenylation Domain That Activates the Nonproteinogenic Amino Acid Capreomycidine in Capreomycin Biosynthesis
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DOI: 10.1002/cbic.202200563
Abstract: Capreomycidine (Cap) is a nonproteinogenic amino acid and building block of nonribosomal peptide (NRP) natural products. We report the formation and activation of Cap in capreomycin biosynthesis. CmnC and CmnD catalyzed hydroxylation and cyclization, respectively,… read more here.
Keywords: nonproteinogenic amino; capreomycin biosynthesis; cap; capreomycidine ... See more keywords
Rational design and exploitation of the molecular diversity space of PRX1‐derived SRX1 peptidic inhibitors containing proteinogenic and nonproteinogenic amino acids
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DOI: 10.1002/jccs.70001
Abstract: The peroxiredoxin‐1 (PRX1) of redox peroxidase reduces reactive oxygen and nitrogen species levels in human cells and can be regulated by its interacting partner sulfiredoxin‐1 (SRX1). A 9‐mer core peptide segment (termed CTTc) located in… read more here.
Keywords: nonproteinogenic amino; amino acids; section; prx1 ... See more keywords
Pyridoxal 5'-Phosphate (PLP)-Dependent β- and γ-Substitution Reactions Forming Nonproteinogenic Amino Acids in Natural Product Biosynthesis.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.4c01226
Abstract: Living organisms synthesize various nonproteinogenic amino acids (NPAAs) as the building blocks of natural products. These NPAAs are often biosynthesized by pyridoxal 5'-phosphate (PLP)-dependent enzymes, which catalyze β- or γ- substitutions. These enzymes contribute to… read more here.
Keywords: plp; nonproteinogenic amino; amino acids; pyridoxal phosphate ... See more keywords