SMG1, a nonsense‐mediated mRNA decay (NMD) regulator, as a candidate therapeutic target in multiple myeloma
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13343
Abstract: Early data suggested that CC‐115, a clinical molecule, already known to inhibit the mammalian target of rapamycin kinase (TORK) and DNA‐dependent protein kinase (DNA‐PK) may have additional targets beyond TORK and DNA‐PK. Therefore, we aimed… read more here.
Keywords: nonsense mediated; smg1; decay nmd; mrna decay ... See more keywords
Variation of the response to metal ions and nonsense‐mediated mRNA decay across different Saccharomyces cerevisiae genetic backgrounds
Sign Up to like & getrecommendations! Published in 2021 at "Yeast"
DOI: 10.1002/yea.3565
Abstract: Regulation of mRNA steady‐state levels is important in controlling gene expression particularly in response to environmental stimuli. This allows cells to rapidly respond to environment changes. The highly conserved nonsense‐mediated mRNA decay (NMD) pathway was… read more here.
Keywords: saccharomyces cerevisiae; response; genetic backgrounds; mediated mrna ... See more keywords
Identifying Cellular Nonsense-Mediated mRNA Decay (NMD) Targets: Immunoprecipitation of Phosphorylated UPF1 Followed by RNA Sequencing (p-UPF1 RIP-Seq).
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7540-2_13
Abstract: Recent progress in the technology of transcriptome-wide high-throughput sequencing has revealed that nonsense-mediated mRNA decay (NMD) targets ~10% of physiologic transcripts for the purpose of tuning gene expression in response to various environmental conditions. Regardless… read more here.
Keywords: decay nmd; phosphorylated upf1; mediated mrna; nmd targets ... See more keywords
Importin β1 mediates nuclear import of the factors associated with nonsense-mediated RNA decay.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.01.034
Abstract: In eukaryotic cells, nonsense-mediated RNA decay (NMD) is an essential physiological mechanism coupled to translation, regulating the stability of abnormal RNA containing premature termination codon (PTC) and a significant fraction of normal transcriptomes. So far,… read more here.
Keywords: smg5 magoh; rna decay; nonsense mediated; mediated rna ... See more keywords
Rotaviral nonstructural protein 5 (NSP5) promotes proteasomal degradation of up-frameshift protein 1 (UPF1), a principal mediator of nonsense-mediated mRNA decay (NMD) pathway, to facilitate infection.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2021.110180
Abstract: Nonsense-mediated mRNA decay (NMD), a cellular RNA quality system, has been shown to be an ancestral form of cellular antiviral response that can restrict viral infection by targeting viral RNA for degradation or other various… read more here.
Keywords: protein; degradation; infection; nmd pathway ... See more keywords
UPF1 reduces C9orf72 HRE-induced neurotoxicity in the absence of nonsense-mediated decay dysfunction
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.108925
Abstract: SUMMARY Multiple cellular pathways have been suggested to be altered by the C9orf72 GGGGCC (G4C2) hexanucleotide repeat expansion (HRE), including aspects of RNA regulation such as nonsense-mediated decay (NMD). Here, we investigate the role that… read more here.
Keywords: hre; mediated decay; neurotoxicity; upf1 reduces ... See more keywords
New insights into no-go, non-stop and nonsense-mediated mRNA decay complexes.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2020.06.011
Abstract: Eukaryotes possess a variety of translational control mechanisms which function in the surveillance of mRNAs, discriminating between normal and aberrant translation elongation and termination, triggering mRNA decay. The three major evolutionarily conserved eukaryotic pathways are… read more here.
Keywords: non stop; mrna decay; mediated mrna; nonsense mediated ... See more keywords
A CRISPR-based Screen Links an Inhibitor of Nonsense-mediated Decay to eIF4A3 Target Engagement.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical biology"
DOI: 10.1021/acschembio.0c00253
Abstract: Eukaryotic initiation factor (eIF) 4A3 is a DEAD-box RNA helicase and a core component of the exon-junction complex (EJC). The EJC marks the location of exon:exon junctions following the removal of introns by splicing and… read more here.
Keywords: crispr; mediated decay; eif4a3; engagement ... See more keywords
Escape from nonsense-mediated decay associates with anti-tumor immunogenicity
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-17526-5
Abstract: Frameshift insertion/deletions (fs-indels) are an infrequent but highly immunogenic mutation subtype. Although fs-indels are degraded through the nonsense-mediated decay (NMD) pathway, we hypothesise that some fs-indels escape degradation and elicit anti-tumor immune responses. Using allele-specific… read more here.
Keywords: escape; mediated decay; nmd escape; anti tumor ... See more keywords
Nonsense-mediated RNA decay in the brain: emerging modulator of neural development and disease
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Neuroscience"
DOI: 10.1038/s41583-018-0079-z
Abstract: Steady-state RNA levels are controlled by the balance between RNA synthesis and RNA turnover. A selective RNA turnover mechanism that has received recent attention in neurons is nonsense-mediated RNA decay (NMD). NMD has been shown to… read more here.
Keywords: neural development; rna decay; nonsense mediated; mediated rna ... See more keywords
Plasmid transfection influences the readout of nonsense-mediated mRNA decay reporter assays in human cells
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-10847-4
Abstract: Messenger RNA (mRNA) turnover is a crucial and highly regulated step of gene expression in mammalian cells. This includes mRNA surveillance pathways such as nonsense-mediated mRNA decay (NMD), which assesses the fidelity of transcripts and… read more here.
Keywords: reporter; transfection; mediated mrna; mrna decay ... See more keywords