Reduction of Nonspecificity Motifs in Synthetic Antibody Libraries.
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DOI: 10.1016/j.jmb.2017.11.008
Abstract: Successful antibody development requires both functional binding and desirable biophysical characteristics. In the current study, we analyze the causes of one hurdle to clinical development, off-target reactivity, or nonspecificity. We used a high-throughput nonspecificity assay… read more here.
Keywords: antibody; nonspecificity; motifs synthetic; reduction nonspecificity ... See more keywords
Nonspecificity in a nonimmune human scFv repertoire
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DOI: 10.1080/19420862.2017.1356528
Abstract: ABSTRACT Efforts to develop effective antibody therapeutics are frequently hampered by issues such as aggregation and nonspecificity, often only detected in late stages of the development process. In this study, we used a high throughput… read more here.
Keywords: nonspecificity nonimmune; family; nonspecificity; human scfv ... See more keywords