Structural and Functional Evaluation of Clinically Relevant Inhibitors of Steroidogenic Cytochrome P450 17A1
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DOI: 10.1124/dmd.117.075317
Abstract: Human steroidogenic cytochrome P450 17A1 (CYP17A1) is a bifunctional enzyme that performs both hydroxylation and lyase reactions, with the latter required to generate androgens that fuel prostate cancer proliferation. The steroid abiraterone, the active form… read more here.
Keywords: functional evaluation; nonsteroidal inhibitors; structural functional; p450 17a1 ... See more keywords