Inhibition of nonstructural protein 15 of SARS‐CoV‐2 by golden spice: A computational insight
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3753
Abstract: The quick widespread of the coronavirus and speedy upsurge in the tally of cases demand the fast development of effective drugs. The uridine‐directed endoribonuclease activity of nonstructural protein 15 (Nsp15) of the coronavirus is responsible… read more here.
Keywords: protein sars; nonstructural protein; inhibition nonstructural; sars cov ... See more keywords
Discovery of a novel antiviral agent targeting the nonstructural protein 4 (nsP4) of chikungunya virus.
Sign Up to like & getrecommendations! Published in 2017 at "Virology"
DOI: 10.1016/j.virol.2017.02.014
Abstract: Chikungunya fever (CHIKF) is caused by chikungunya virus (CHIKV) infection which is a re-emerging mosquito-borne zoonosis. At present, there are no approved therapeutics for CHIKF. Herein, we have investigated candidate compounds which can inhibit CHIKV… read more here.
Keywords: protein nsp4; nonstructural protein; compound; chikungunya virus ... See more keywords
Structural, Biophysical, and Biochemical Elucidation of the SARS-CoV-2 Nonstructural Protein 3 Macro Domain
Sign Up to like & getrecommendations! Published in 2020 at "ACS Infectious Diseases"
DOI: 10.1021/acsinfecdis.0c00441
Abstract: The pandemic outbreak of a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has threatened the global public health and economy since late December 2019. SARS-CoV-2 encodes the conserved macro domain within nonstructural protein… read more here.
Keywords: sars cov; nonstructural protein; structural biophysical; macro domain ... See more keywords
Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab1302
Abstract: Abstract Alphaviruses such as Ross River virus (RRV), chikungunya virus (CHIKV), Sindbis virus (SINV), and Venezuelan equine encephalitis virus (VEEV) are mosquito-borne pathogens that can cause arthritis or encephalitis diseases. Nonstructural protein 4 (nsP4) of… read more here.
Keywords: protein nsp4; rna dependent; dependent rna; nonstructural protein ... See more keywords
A fijiviral nonstructural protein triggers cell death in plant and bacterial cells via its transmembrane domain
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Plant Pathology"
DOI: 10.1111/mpp.13277
Abstract: Abstract Southern rice black‐streaked dwarf virus (SRBSDV; Fijivirus, Reoviridae) has become a threat to cereal production in East Asia in recent years. Our previous cytopathologic studies have suggested that SRBSDV induces a process resembling programmed… read more here.
Keywords: cell death; nonstructural protein; death; plant ... See more keywords
Enterovirus A71 Promotes Exosome Secretion by the Nonstructural Protein 3A Interacting with Rab27a
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.03446-22
Abstract: Research has shown that viral infection impacts exosome secretion, but its regulation mechanisms remain poorly understood. Nonstructural protein 3A of EV-A71 interacts with many host factors and is involved in the remodeling of cellular membranes.… read more here.
Keywords: exosome secretion; infection; secretion; nonstructural protein ... See more keywords
Nanobead-Based Screening Method for Antibody Pairing of Dengue Virus Nonstructural Protein-1.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of biomedical nanotechnology"
DOI: 10.1166/jbn.2021.3148
Abstract: Dengue fever is a classic mosquito viral disease. Dengue virus non-structural protein-1 as a membrane-associated homologous dimer anchored to the surface of infected cells and also secreted into the blood. The nonstructural protein-1 levels are… read more here.
Keywords: protein; nonstructural protein; dengue virus; antibody ... See more keywords
In-Vitro Transcription analysis of NS5A from HCV-3a circulating in Pakistani patients with chronic hepatitis C and their differential response to antiviral therapy
Sign Up to like & getrecommendations! Published in 2017 at "Pakistan Journal of Medical Sciences"
DOI: 10.12669/pjms.335.12973
Abstract: Objective: Mutations in HCV nonstructural protein 5A (NS5A) play a vital role in virus resistance. The aim of this study was to develop a correlation between NS5A mutations (genotype 3a) and virological response towards interferon… read more here.
Keywords: response; nonstructural protein; hcv; non responders ... See more keywords
Dengue virus nonstructural protein 1 activates platelets via Toll-like receptor 4, leading to thrombocytopenia and hemorrhage
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1007625
Abstract: Dengue virus (DENV) infection, the most common mosquito-transmitted viral infection, can cause a range of diseases from self-limiting dengue fever to life-threatening dengue hemorrhagic fever and shock syndrome. Thrombocytopenia is a major characteristic observed in… read more here.
Keywords: dengue virus; denv; nonstructural protein; thrombocytopenia hemorrhage ... See more keywords
2017 KASL clinical practice guidelines management of hepatitis C: Treatment of chronic hepatitis C
Sign Up to like & getrecommendations! Published in 2018 at "Clinical and Molecular Hepatology"
DOI: 10.3350/cmh.2018.1004
Abstract: AGREE, Appraisal of guidelines for research and evaluation; ALT, alanine aminotransferase; anti-HCV, antibody to hepatitis C; APRI, aminotransferaseto-platelet ratio index; AST, aspartate aminotransferase; ASV, asunaprevir; AUC, area under the curve; /r, /ritonavir; CTP, Child-Pugh Turcotte;… read more here.
Keywords: kasl clinical; kasl; hepatitis; nonstructural protein ... See more keywords
Newcastle Disease Virus Nonstructural V Protein Upregulates SOCS3 Expression to Facilitate Viral Replication Depending on the MEK/ERK Pathway
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2019.00317
Abstract: Newcastle disease virus (NDV) causes serious economic losses to the poultry industry. In our previous study, we found that NDV induced a strong innate immune response in the chicken embryo and bursa of Fabricius (BF).… read more here.
Keywords: mek erk; socs3; nonstructural protein; expression ... See more keywords