Polymorphism Data Assist Estimation of the Nonsynonymous over Synonymous Fixation Rate Ratio ω for Closely Related Species
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DOI: 10.1093/molbev/msz203
Abstract: Abstract The ratio of nonsynonymous over synonymous sequence divergence, dN/dS, is a widely used estimate of the nonsynonymous over synonymous fixation rate ratio ω, which measures the extent to which natural selection modulates protein sequence… read more here.
Keywords: estimation; closely related; divergence; nonsynonymous synonymous ... See more keywords
Nonsynonymous, synonymous and nonsense mutations in human cancer-related genes undergo stronger purifying selections than expectation
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DOI: 10.1186/s12885-019-5572-x
Abstract: BackgroundNonsynonymous mutations change the protein sequences and are frequently subjected to natural selection. The same goes for nonsense mutations that introduce pre-mature stop codons into CDSs (coding sequences). Synonymous mutations, however, are intuitively thought to… read more here.
Keywords: synonymous nonsense; cancer related; nonsynonymous synonymous; related genes ... See more keywords
Nonsynonymous synonymous variants demand for a paradigm shift in genetics
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DOI: 10.2174/1389202924666230417101020
Abstract: Synonymous (also known as silent) variations are by definition not considered to change the coded protein. Still many variations in this category affect either protein abundance or properties. As this situation is confusing, we have… read more here.
Keywords: genetics; synonymous variations; variation; nonsynonymous synonymous ... See more keywords