Regulation of the Genes Encoding the ppN/OFQ and NOP Receptor.
Sign Up to like & getrecommendations! Published in 2019 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2018_196
Abstract: Over the years, the ability of N/OFQ-NOP receptor system in modulating several physiological functions, including the release of neurotransmitters, anxiety-like behavior responses, modulation of the reward circuitry, inflammatory signaling, nociception, and motor function, has been… read more here.
Keywords: genes encoding; ofq nop; nop receptor; ppn ofq ... See more keywords
NOP-Targeted Nonpeptide Ligands.
Sign Up to like & getrecommendations! Published in 2019 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2019_213
Abstract: The development of nonpeptide systemically active small-molecule NOP-targeted ligands has contributed tremendously to validating the NOP receptor as a promising target for therapeutics. Although a NOP-targeted compound is not yet approved for clinical use, a… read more here.
Keywords: nop targeted; nop receptor; nop ligands; targeted nonpeptide ... See more keywords
Analysis of the distribution of spinal NOP receptors in a chronic pain model using NOP‐eGFP knock‐in mice
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14225
Abstract: The nociceptin/orphanin FQ opioid peptide (NOP) receptor system plays a significant role in the regulation of pain. This system functions differently in the spinal cord and brain. The mechanism by which the NOP receptor agonists… read more here.
Keywords: spinal nop; analysis distribution; nop receptor; pain ... See more keywords
Nociceptin/Orphanin FQ (N/OFQ) conjugated to ATTO594: a novel fluorescent probe for the N/OFQ (NOP) receptor
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14504
Abstract: The nociceptin/orphanin FQ (N/OFQ) receptor (NOP) is a member of the opioid receptor family and is involved in a number of physiological responses, pain and immune regulation as examples. In this study, we conjugated a… read more here.
Keywords: receptor; nociceptin orphanin; nop receptor; orphanin ofq ... See more keywords
Managing Parkinson's disease: moving ON with NOP
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14893
Abstract: The opioid‐like neuropeptide nociceptin/orphanin FQ (N/OFQ) and its receptor (NOP receptor) contribute to Parkinson's disease (PD) and motor complications associated with levodopa therapy. The N/OFQ–NOP receptor system is expressed in cortical and subcortical motor areas… read more here.
Keywords: disease moving; nop receptor; managing parkinson; parkinson disease ... See more keywords
Nociceptin/orphanin FQ peptide receptor-related ligands as novel analgesics.
Sign Up to like & getrecommendations! Published in 2020 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026620666200508082615
Abstract: Despite similar distribution patterns and intracellular events observed in the nociceptin/orphanin FQ peptide (NOP) receptor and other opioid receptors, NOP receptor activation displays unique pharmacological profiles. Several researchers have identified a variety of peptide and… read more here.
Keywords: receptor activation; peptide; nociceptin orphanin; nop receptor ... See more keywords
Role of Nociceptin/Orphanin FQ-NOP Receptor System in the Regulation of Stress-Related Disorders
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms222312956
Abstract: Nociceptin/orphanin FQ (N/OFQ) is a 17-residue neuropeptide that binds the nociceptin opioid-like receptor (NOP). N/OFQ exhibits nucleotidic and aminoacidics sequence homology with the precursors of other opioid neuropeptides but it does not activate either MOP,… read more here.
Keywords: system; stress; nop receptor; role ... See more keywords
Spotlight on Nociceptin/Orphanin FQ Receptor in the Treatment of Pain
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27030595
Abstract: In our society today, pain has become a main source of strain on most individuals. It is crucial to develop novel treatments against pain while focusing on decreasing their adverse effects. Throughout the extent of… read more here.
Keywords: nop receptor; pain; orphanin receptor; spotlight nociceptin ... See more keywords