New approaches for the quantification and targeting of noradrenergic dysfunction in Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51539
Abstract: There is clear, early noradrenergic dysfunction in Alzheimer's disease. This is likely secondary to pathological tau deposition in the locus coeruleus, the pontine nucleus that produces and releases noradrenaline, prior to involvement of cortical brain… read more here.
Keywords: alzheimer disease; dysfunction; dysfunction alzheimer; noradrenergic dysfunction ... See more keywords
Long Road to Ruin: Noradrenergic Dysfunction in Neurodegenerative Disease
Sign Up to like & getrecommendations! Published in 2018 at "Trends in Neurosciences"
DOI: 10.1016/j.tins.2018.01.010
Abstract: It has been known for decades that degeneration of the locus coeruleus (LC), the major noradrenergic nucleus in the brain, occurs in both Alzheimer's disease (AD) and Parkinson's disease (PD), but it was given scant… read more here.
Keywords: ruin noradrenergic; road ruin; dysfunction; disease ... See more keywords
Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases
Sign Up to like & getrecommendations! Published in 2019 at "Brain"
DOI: 10.1093/brain/awz193
Abstract: The locus coeruleus is the site of the earliest pathological changes in many neurodegenerative diseases. Betts et al. describe how in vivo locus coeruleus imaging can be used as a biomarker for noradrenergic dysfunction in… read more here.
Keywords: biomarker noradrenergic; neurodegenerative diseases; locus coeruleus; noradrenergic dysfunction ... See more keywords
Noradrenergic Dysfunction in Alzheimer's and Parkinson's Diseases—An Overview of Imaging Studies
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2018.00127
Abstract: Noradrenergic dysfunction contributes to cognitive impairment in Alzheimer's Disease (AD) and Parkinson's Disease (PD). Conventional therapeutic strategies seek to enhance cholinergic and dopaminergic neurotransmission in AD and PD, respectively, and few studies have examined noradrenergic… read more here.
Keywords: dysfunction alzheimer; dysfunction; imaging studies; noradrenergic dysfunction ... See more keywords